Evidence map›Paper›PMID 24978464›Full record

ReviewNanomedicine (London, England)2014

Targeted radiotherapy with gold nanoparticles: current status and future perspectives.

Wilfred Ngwa, Rajiv Kumar, Srinivas Sridhar, Houari Korideck, Piotr Zygmanski, Robert A Cormack, Ross Berbeco, G Mike Makrigiorgos

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Review
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  11. Article
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  16. Article
  17. A model of modifiedRSC advances · 2021
    Article
  18. Article
  19. Article
  20. Current role of nanoparticles in the treatment of lung cancer.Journal of clinical and translational research · 2021
    Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wilfred NgwaDepartment of Radiation Oncology, Dana-Farber Cancer Institute, Brigham & Women's Hospital & Harvard Medical School, Boston, MA 02215, USA.
Rajiv Kumar
Srinivas Sridhar
Houari Korideck
Piotr Zygmanski
Robert A Cormack
Ross Berbeco
G Mike Makrigiorgos

Funding

Brachytherapy in situ dose-painting administered via gold-nanoparticle elutersK01CA172478 · NCI · DANA-FARBER CANCER INST · PI NGWA, WILFRED · 2013 to 2017
$883k
High Z Oraya Therapy for wet AMDR41EY024197 · NEI · ORAYA THERAPEUTICS, INC · PI CHELL, ERIK WILLIAM, MAKRIGIORGOS, G. MIKE · 2014 to 2014
$215k
Enhancing tumor vascular damage with gold nanoparticles aided radiation therapyR03CA164645 · NCI · DANA-FARBER CANCER INST · PI BERBECO, ROSS I. · 2012 to 2013
$165k
NCI NIH HHS K01 CA172478NCI NIH HHS R03 CA164645NEI NIH HHS R41 EY024197
6 · The paper itself

Abstract

Radiation therapy (RT) is the treatment of cancer and other diseases with ionizing radiation. The ultimate goal of RT is to destroy all the disease cells while sparing healthy tissue. Towards this goal, RT has advanced significantly over the past few decades in part due to new technologies including: multileaf collimator-assisted modulation of radiation beams, improved computer-assisted inverse treatment planning, image guidance, robotics with more precision, better motion management strategies, stereotactic treatments and hypofractionation. With recent advances in nanotechnology, targeted RT with gold nanoparticles (GNPs) is actively being investigated as a means to further increase the RT therapeutic ratio. In this review, we summarize the current status of research and development towards the use of GNPs to enhance RT. We highlight the promising emerging modalities for targeted RT with GNPs and the corresponding preclinical evidence supporting such promise towards potential clinical translation. Future prospects and perspectives are discussed.

Indexed as

GoldHumansMetal NanoparticlesNanomedicineNanotechnologyNeoplasmsGoldcancergold nanoparticlenanomedicineradiotherapyretinal disease

Identifiers

PMID24978464
PMCPMC4143893

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.