ArticleNature communications2014
Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- B cell receptor ligation induces IgE plasma cell elimination.The Journal of experimental medicine · 2023Article
- The RNA-binding protein hnRNP F is required for the germinal center B cell response.Nature communications · 2023Article
- The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2.Cell death & disease · 2023Article
- Bruton's tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response.Cell death & disease · 2021Article
- Efficient homing of antibody-secreting cells to the bone marrow requires RNA-binding protein ZFP36L1.The Journal of experimental medicine · 2021Article
- Article
- Review
- Two DuplicatedFrontiers in immunology · 2021Article
- Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.Frontiers in immunology · 2020Article
- B Cell-Intrinsic SHP1 Expression Promotes the Gammaherpesvirus-Driven Germinal Center Response and the Establishment of Chronic Infection.Journal of virology · 2019Article
- A signalling cascade involving receptor-activated phospholipase ACell communication and signaling : CCS · 2019Article
- In the Right Place, at the Right Time: Spatiotemporal Conditions Determining Plasma Cell Survival and Function.Frontiers in immunology · 2019Review
- Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity.Frontiers in immunology · 2018Review
- Shp1 function in myeloid cells.Journal of leukocyte biology · 2017Review
- Tyrosine kinase c-Abl regulates the survival of plasma cells.Scientific reports · 2017Article
- Article
- Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis.Stem cell reports · 2016Article
- Loss of miR-182 affects B-cell extrafollicular antibody response.Immunology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germline or B-cell-specific loss of Ptpn6 gene encoding the Shp1 protein tyrosine phosphatase leads to skewed B lymphopoiesis and systemic autoimmunity. Here, to study its role in B-cell terminal differentiation, we generated Ptpn6(f/f)Aicda(Cre/+) mice with Shp1 ablated only in activated B cells. We show that Ptpn6(f/f)Aicda(Cre/+) mice have normal B-cell development but exhibit defective class-switched primary and recalled antibody response to a T-cell-dependent antigen. Germinal centres are present but do not persist and memory B cells are not formed. Interestingly, Shp1-deficient plasma cells are generated in the spleen but do not contribute to the bone marrow long-lived pool. Plasma cells lacking Shp1 exhibit aberrant α4β1 integrin activation due to dysregulated Src- and PI3-kinase signalling and manifest attenuated migration in vitro and defective bone marrow homing when reconstituted in vivo. Interrupting α4β1-VCAM-1 interaction rectifies this defect. These data suggest that Shp1 signalling is required for the establishment of a life-long protective humoral immunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.