ArticlePloS one2014
Substrate-dependent evolution of cytochrome P450: rapid turnover of the detoxification-type and conservation of the biosynthesis-type.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Sexually dimorphic expression and hormonal responsiveness of steroidogenic Cyp genes during gonadal differentiation in mandarin fish.Fish physiology and biochemistry · 2026Article
- Evolutionary trajectories, early diversification, and species-specific amplification of the metazoan inhibitor of apoptosis (IAP) repertoire.Molecular biology and evolution · 2026Article
- Hyper-specialized primates possess a reduced suite of xenobiotic-metabolizing cytochrome P450 genes.Molecular phylogenetics and evolution · 2026Article
- In Silico Analysis of Two Hard Tick P450s: Identification, Characterization, and Putative Metabolism ofInternational journal of molecular sciences · 2025Article
- Genome-wide identification of the cytochrome P450 superfamily in Trichoplusia ni and in-silico expression of resistance against HDAC inhibitors.Scientific reports · 2025Article
- Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function.PLoS genetics · 2025Article
- Very important pharmacogenetic variants landscape and potential clinical relevance in the Zhuang population from Yunnan province.Scientific reports · 2024Article
- Phylogenomics of the Ecdysteroid Kinase-like (EcKL) Gene Family in Insects Highlights Roles in Both Steroid Hormone Metabolism and Detoxification.Genome biology and evolution · 2024Article
- Insights into the adaptive evolution of chromosome and essential traits through chromosome-level genome assembly ofiScience · 2024Article
- After a Century of Research into Environmental Mutagens and Carcinogens, Where Do We Stand?International journal of environmental research and public health · 2023Review
- Specific Gene Duplication and Loss of Cytochrome P450 in Families 1-3 in Carnivora (Mammalia, Laurasiatheria).Animals : an open access journal from MDPI · 2022Article
- Controlling the Substrate Specificity of an Enzyme through Structural Flexibility by Varying the Salt-Bridge Density.Molecules (Basel, Switzerland) · 2021Article
- A Review of the Important Role ofGenes · 2020Review
- Dynamics and Mechanism of Binding of Androstenedione to Membrane-Associated Aromatase.Biochemistry · 2020Article
- Article
- How interactions with plant chemicals shape insect genomes.Current opinion in insect science · 2019Review
- Complex gene expansion of theEcology and evolution · 2018Article
- Rapid birth-death evolution and positive selection in detoxification-type glutathione S-transferases in mammals.PloS one · 2018Article
- Natural diversity facilitates the discovery of conserved chemotherapeutic response mechanisms.Current opinion in genetics & development · 2017Review
- Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the cytochrome P450 family are important metabolic enzymes that are present in all metazoans. Genes encoding cytochrome P450s form a multi-gene family, and the number of genes varies widely among species. The enzymes are classified as either biosynthesis- or detoxification-type, depending on their substrates, but their origin and evolution have not been fully understood. In order to elucidate the birth and death process of cytochrome P450 genes, we performed a phylogenetic analysis of 710 sequences from 14 vertebrate genomes and 543 sequences from 6 invertebrate genomes. Our results showed that vertebrate detoxification-type genes have independently emerged three times from biosynthesis-type genes and that invertebrate detoxification-type genes differ from vertebrates in their origins. Biosynthetic-type genes exhibit more conserved evolutionary processes than do detoxification-type genes, with regard to the rate of gene duplication, pseudogenization, and amino acid substitution. The differences in the evolutionary mode between biosynthesis- and detoxification-type genes may reflect differences in their respective substrates. The phylogenetic tree also revealed 11 clans comprising an upper category to families in the cytochrome P450 nomenclature. Here, we report novel clan-specific amino acids that may be used for the qualitative definition of clans.
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