Evidence map›Paper›PMID 24977474›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2014

Clinical performance of digital cervicography and cytology for cervical cancer screening in HIV-infected women in Lusaka, Zambia.

Allen C Bateman, Groesbeck P Parham, Vikrant V Sahasrabuddhe, Mulindi H Mwanahamuntu, Sharon Kapambwe, Katundu Katundu, Theresa Nkole, Jacqueline Mulundika, Krista S Pfaendler, Michael L Hicks and 4 more

Abstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Allen C Bateman*Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; †University of North Carolina at Chapel Hill, Chapel Hill, NC; ‡University Teaching Hospital, Lusaka, Zambia; §Vanderbilt University, Nashville, TN; ‖University of Cincinnati, Cincinnati, OH; and ¶Michigan Cancer Institute, Pontiac, MI.
Groesbeck P Parham
Vikrant V Sahasrabuddhe
Mulindi H Mwanahamuntu
Sharon Kapambwe
Katundu Katundu
Theresa Nkole
Jacqueline Mulundika
Krista S Pfaendler
Michael L Hicks
Aaron Shibemba
Sten H Vermund
Jeffrey S A Stringer
Carla J Chibwesha

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OLAF KUTSCH · 1988 to 2026
$84.1M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32CA060396 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRISTOW, ROBERT EDWARD · 1994 to 2020
$4.6M
Zambian Cervical Cancer Research Capacity InitiativeD43CA153784 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PARHAM, GROESBECK PREER · 2010 to 2013
$1.8M
FIC NIH HHS R24 TW007988FIC NIH HHS R24TW007988FIC NIH HHS R25 TW009340FIC NIH HHS R25TW009340NCI NIH HHS 1D43CA153784NCI NIH HHS D43 CA153784NCI NIH HHS P30 CA016086NCI NIH HHS T32 CA060396NIAID NIH HHS 3P30AI027767-19NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050410
6 · The paper itself

Abstract

Although there is a growing literature on the clinical performance of visual inspection with acetic acid in HIV-infected women, to the best of our knowledge, none have studied visual inspection with acetic acid enhanced by digital cervicography. We estimated clinical performance of cervicography and cytology to detect cervical intraepithelial neoplasia grade 2 or worse. Sensitivity and specificity of cervicography were 84% [95% confidence interval (CI): 72 to 91) and 58% (95% CI: 52 to 64). At the high-grade squamous intraepithelial lesion or worse cutoff for cytology, sensitivity and specificity were 61% (95% CI: 48 to 72) and 58% (95% CI: 52 to 64). In our study, cervicography seems to be as good as cytology in HIV-infected women.

Indexed as

Acetic AcidAdultColposcopyCytological TechniquesFemaleHIV InfectionsHumansMass ScreeningMiddle AgedOptical ImagingSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsYoung AdultZambiaAcetic Acid

Identifiers

PMID24977474
PMCPMC4162769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.