ArticlePloS one2014
Gaussian mixture modeling of hemispheric lateralization for language in a large sample of healthy individuals balanced for handedness.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 3 of them syntheses that pooled it.
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Who cites it
126 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Functional and oncological outcomes after right hemisphere glioma resection in awake versus asleep patients: a systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Functional neuroanatomy of language without speech: An ALE meta-analysis of sign language.Human brain mapping · 2021Pooled it
- Language and reading impairments are associated with increased prevalence of non-right-handedness.Child developmentPooled it
- A CBF decrease in the left supplementary motor areas: New insight into postoperative pediatric cerebellar mutism syndrome using arterial spin labeling perfusion MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Trial
- Parallel but independent reduction of emotional awareness and corpus callosum connectivity in older age.PloS one · 2018Trial
- A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks.Nature communications · 2026Article
- Variations of global brain asymmetry are associated with aging and related diseases.Science advances · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Language laterality and cognitive skills: does anatomy matter?Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Stronger right-hemispheric involvement in language processing is associated with greater functional connectivity between the left-lateralized language-related network and the cingulo-opercular network.Brain structure & function · 2026Article
- Manifold lateralisation and variability in the language connectome at 7T.Research square · 2026Article
- Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis.Brain structure & function · 2026Article
- Structural and functional atypicality in the temporal cortex are associated with auditory perception in maltreated children.Scientific reports · 2026Article
- Predominantly left-lateralized EEG-EMG associations following gamma-theta stimulation in older adults with mild cognitive impairment.Frontiers in aging neuroscience · 2026Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- Dynamic Causal Tractography Analysis of Auditory Descriptive Naming: An Intracranial Study of 106 Patients.NeuroImage · 2025Article
- A new instrument for the assessment of laterality: evidence from confirmatory analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Cortical neural activity during responses to mechanical perturbation: Effects of hand preference and hand used.NeuroImage · 2025Article
- Facial emotion processing hemispheric bias is weakly associated with handedness, autistic traits and biological sex, but not age.BMC psychology · 2025Article
- Consensus recommendations for clinical functional MRI applied to language mapping.Aperture neuro · 2025Article
66 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
Hemispheric lateralization for language production and its relationships with manual preference and manual preference strength were studied in a sample of 297 subjects, including 153 left-handers (LH). A hemispheric functional lateralization index (HFLI) for language was derived from fMRI acquired during a covert sentence generation task as compared with a covert word list recitation. The multimodal HFLI distribution was optimally modeled using a mixture of 3 and 4 Gaussian functions in right-handers (RH) and LH, respectively. Gaussian function parameters helped to define 3 types of language hemispheric lateralization, namely "Typical" (left hemisphere dominance with clear positive HFLI values, 88% of RH, 78% of LH), "Ambilateral" (no dominant hemisphere with HFLI values close to 0, 12% of RH, 15% of LH) and "Strongly-atypical" (right-hemisphere dominance with clear negative HFLI values, 7% of LH). Concordance between dominant hemispheres for hand and for language did not exceed chance level, and most of the association between handedness and language lateralization was explained by the fact that all Strongly-atypical individuals were left-handed. Similarly, most of the relationship between language lateralization and manual preference strength was explained by the fact that Strongly-atypical individuals exhibited a strong preference for their left hand. These results indicate that concordance of hemispheric dominance for hand and for language occurs barely above the chance level, except in a group of rare individuals (less than 1% in the general population) who exhibit strong right hemisphere dominance for both language and their preferred hand. They call for a revisit of models hypothesizing common determinants for handedness and for language dominance.
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