ArticlePloS one2014
Contextual and auditory fear conditioning continue to emerge during the periweaning period in rats.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- The effects of acid-sensing ion channel-1A on conditioned fear memory are age-dependent.IBRO neuroscience reports · 2026Article
- Postnatal maturation of the basolateral and paralaminar amygdala in rodents: implications for social-emotional development.Frontiers in neuroscience · 2026Review
- Reversible Suppression of Fear Memory Recall by Transient Circadian Arrhythmia.Frontiers in integrative neuroscience · 2022Article
- Article
- Neonatal pain and stress disrupts later-life pavlovian fear conditioning and sensory function in rats: Evidence for a two-hit model.Developmental psychobiology · 2018Article
- FAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats.Behavioural brain research · 2016Article
- Limbic system development underlies the emergence of classical fear conditioning during the third and fourth weeks of life in the rat.Behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Anxiety disorders often emerge during childhood. Rodent models using classical fear conditioning have shown that different types of fear depend upon different neural structures and may emerge at different stages of development. For example, some work has suggested that contextual fear conditioning generally emerges later in development (postnatal day 23-24) than explicitly cued fear conditioning (postnatal day 15-17) in rats. This has been attributed to an inability of younger subjects to form a representation of the context due to an immature hippocampus. However, evidence that contextual fear can be observed in postnatal day 17 subjects and that cued fear conditioning continues to emerge past this age raises questions about the nature of this deficit. The current studies examine this question using both the context pre-exposure facilitation effect for immediate single-shock contextual fear conditioning and traditional cued fear conditioning using Sprague-Dawley rats. The data suggest that both cued and contextual fear conditioning are continuing to develop between PD 17 and 24, consistent with development occurring the in essential fear conditioning circuit.
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Registered trials
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