ArticleJournal of thrombosis and haemostasis : JTH2014
Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based cohort study from England.
Article in Journal of thrombosis and haemostasis : JTH, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Postoperative bleeding and venous thromboembolism in colorectal cancer patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Article
- The Role of KRAS Mutation in Colorectal Cancer-Associated Thrombosis.International journal of molecular sciences · 2023Article
- Preoperative D-dimer Value and Lower Limb Venous Ultrasound for Deep Venous Thrombosis Prevents Postoperative Symptomatic Venous Thromboembolism in Patients Undergoing Colorectal Surgery: A Retrospective Study.Journal of the anus, rectum and colon · 2023Article
- Incidence and risk factors for venous thromboembolism, bleeding, and death in colorectal cancer (Cancer-VTE Registry).Cancer science · 2022Article
- Time trends in the incidence rates of venous thromboembolism following colorectal resection by indication and operative technique.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- Risk factors for venous thromboembolism in metastatic colorectal cancer with contemporary treatment: A SEER-Medicare analysis.Cancer medicine · 2022Article
- Clinical analysis of postoperative venous thromboembolism in Japanese patients after colorectal cancer surgery.Surgery today · 2021Article
- Epidemiology of Venous Thromboembolism After Second Cancer.Clinical epidemiology · 2020Article
- The Incidence of Deep Vein Thrombosis in Breast Cancer Patients Receiving Outpatient Cancer Therapy in Iran.Tanaffos · 2019Article
- Long-Term Incidence of Venous Thromboembolism in Cancer: The Scandinavian Thrombosis and Cancer Cohort.TH open : companion journal to thrombosis and haemostasis · 2018Article
- Colorectal cancer and thrombosis.International journal of colorectal disease · 2018Article
- Characterisation and risk assessment of venous thromboembolism in gastrointestinal cancers.World journal of gastrointestinal oncology · 2017Article
- Linked hospital and primary care database analysis of the impact of short-term complications on recurrence in laparoscopic inguinal hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2017Article
- Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data.British journal of cancer · 2016Article
- Article
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5 authors.
Funding
Abstract
backgroundPatients with colorectal cancer are at high risk of developing venous thromboembolism(VTE), and recent international guidelines have advised extended prophylaxis for some of these patients following surgery or during chemotherapy. However, our understanding of which patients are at increased risk, and to what extent, is limited.
objectivesTo determine absolute and relative rates of VTE among patients with colorectal cancer according to Dukes stage, surgical intervention,and chemotherapy.
methodsWe analyzed data from four linked databases from 1997 to 2006: the Clinical Practice Research Datalink, linked to Hospital Episode Statistics, Cancer Registry data, and Office for National Statistics cause of death data, all from England. Rates were compared by the use of Cox regression.
resultsThere were 10 309 patients with colorectal cancer, and 555 developed VTE (5.4%). The incidence varied by Dukes stage, being three-fold higher among Dukes D patients than among Dukes A patients (hazard ratio [HR] 3.08, 95% confidence interval [CI] 1.95–4.84), and 40% higher for those receiving chemotherapy than for those not receiving chemotherapy(HR 1.39, 95% CI 1.14–1.69). The risk following surgery varied by stage of disease and chemotherapy, with Dukes A patients having a low incidence of VTE (0.74%; 95% CI 0.28–1.95) at 6 months,with all events occurring within 28 days of surgery, as compared with Dukes B and Dukes C patients, whose risk at 6 months was ~ 2%.
conclusionTwenty-eight days of prophylaxis following surgery for colorectal cancer is appropriate for Dukes A patients. However, Dukes B and Dukes C patients receiving postoperative chemotherapy have a longer duration of risk.
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