ArticleTheScientificWorldJournal2014
Mycoplasma pneumoniae infection in children is a risk factor for developing allergic diseases.
Article in TheScientificWorldJournal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Serum Tumor Necrosis Factor-Canadian respiratory journal · 2018Pooled it
- Role of the Notch ligand DLL4 in the immune response of children with Mycoplasma pneumoniae pneumonia.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Construction and validation of a nomogram model to predict bronchiolitis Mycoplasma pneumoniae pneumonia in children.Scientific reports · 2024Article
- Association of atopy with disease severity in children withFrontiers in pediatrics · 2023Article
- Metabolism Characteristics ofAllergy, asthma & immunology research · 2022Article
- Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics.International journal of environmental research and public health · 2021Review
- Increased Total Serum Immunoglobulin E Is Likely to Cause Complications ofFrontiers in cellular and infection microbiology · 2021Article
- Impact of atopy on the severity and extrapulmonary manifestations of childhood Mycoplasma pneumoniae pneumonia.Journal of clinical laboratory analysis · 2019Article
- Assessment of levels of D-dimer and interferon-γ in pediatric patients withExperimental and therapeutic medicine · 2018Article
- Profiling inflammatory markers in patients with pneumonia on intensive care.Scientific reports · 2018Article
- Interleukin 17A as a good predictor of the severity of Mycoplasma pneumoniae pneumonia in children.Scientific reports · 2017Article
- Utility of cytokines to predict neonatal sepsis.Pediatric research · 2017Article
- Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency.Human genomics · 2017Article
- Commentary: Basophil Activation-Dependent Autoantibody and Interleukin-17 Production Exacerbate Systemic Lupus Erythematosus.Frontiers in immunology · 2017Article
- Insights into the pathogenesis of Mycoplasma pneumoniae (Review).Molecular medicine reports · 2016Review
- Is There any Relationship Between Extra-Pulmonary Manifestations of Mycoplasma Pneumoniae Infection and Atopy/Respiratory Allergy in Children?Pediatric reports · 2016Article
- Th1/Th2 Cytokine Profile and Its Diagnostic Value in Mycoplasma pneumoniae Pneumonia.Iranian journal of pediatrics · 2016Article
- Relationship between immune parameters and organ involvement in children with Henoch-Schonlein purpura.PloS one · 2014Observational
- Circulating CC16, immune response to Mycoplasma pneumoniae and lung function: a population-based, multi-cohort study.Respiratory medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycoplasma pneumoniae (MP) infection is the dominant cause of pneumonia in children. We sought to determine the relationship between MP infection and secondary allergic disease and to clarify the associated mechanisms of inflammatory response. A prospective study was performed among 1330 patients diagnosed with pneumonia to investigate the patient immune status by determining the correlation between MP infection, immunoglobulin E (IgE) levels, and a spectrum of associated serum cytokines. Serum IgE, IL-4, IL-6, and IL-10 levels for MPP patients in the acute phase were obviously higher than those in the recovery phase (P < 0.01). MPP patients with allergic conditions had increased serum IgE levels and increased IL-4/INF- γ ratio, and IgE and Eosinophil Cationic Protein were further elevated in patients who eventually developed secondary asthma changes. Patients with severe pneumonia and high clinical pulmonary infection scores presented higher levels of IL-4 and IL-5 in serum than those with low scores (P < 0.01). The proportion of CD4+ and CD8+ T cells that secreted IL-4 was significantly increased in MPP patients with elevated IgE. Our data demonstrate a significant correlation between MP infection and IgE levels, which is associated with a Th1/Th2 cytokine imbalance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.