ArticleISRN pharmacology2014
Antifungal, Antileishmanial, and Cytotoxicity Activities of Various Extracts of Berberis vulgaris (Berberidaceae) and Its Active Principle Berberine.
Article in ISRN pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Improving the Antimicrobial Potency of Berberine for Endodontic Canal Irrigation Using Polymeric Nanoparticles.Pharmaceutics · 2024Article
- Assessment of Anticancer Properties ofPlants (Basel, Switzerland) · 2024Article
- Antimicrobial activities and mechanisms of extract and components of herbs in East Asia.RSC advances · 2022Review
- Antioxidant, Antibacterial, and Antifungal Activities of the Ethanolic Extract Obtained fromMolecules (Basel, Switzerland) · 2022Article
- 3D printing of nanocomposite pills through desktop vat photopolymerization (stereolithography) for drug delivery reasons.3D printing in medicine · 2022Article
- Study on the mechanisms of action of berberine combined with fluconazole against fluconazole-resistant strains ofFrontiers in microbiology · 2022Article
- The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade.Natural products and bioprospecting · 2021Review
- Metabolic, structural, and proteomic changes in Candida albicans cells induced by the protein-carbohydrate fraction of Dendrobaena veneta coelomic fluid.Scientific reports · 2021Article
- Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review.Antibiotics (Basel, Switzerland) · 2021Review
- Evaluation of Berberine as an Adjunct to TB Treatment.Frontiers in immunology · 2021Article
- Anti-Leishmanial Effects of Chitosan-Polyethylene Oxide Nanofibers Containing Berberine: An Applied Model for Leishmania Wound Dressing.Iranian journal of medical sciences · 2020Article
- Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds.Malaria journal · 2020Article
- Antibacterial activities, proposed mode of action and cytotoxicity of leaf extracts from Triumfetta welwitschii against Pseudomonas aeruginosa.BMC complementary and alternative medicine · 2019Article
- Protective effect of berberine on aconite‑induced myocardial injury and the associated mechanisms.Molecular medicine reports · 2018Article
- In Vitro Study of Antiamoebic Activity of Methanol Extracts ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018Article
- Toxicology effects ofIranian journal of basic medical sciences · 2017Review
- Antifungal Compounds againstBioMed research international · 2017Review
- In vitro toxicity determination of antifungal constituents from Combretum zeyheri.BMC complementary and alternative medicine · 2016Article
- Evaluation of the antifungal activities of various extracts fromCurrent medical mycology · 2015Article
- Plant-derived compounds in treatment of leishmaniasis.Iranian journal of veterinary research · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, in vitro antidermatophytic activity against Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, and Microsporum gypseum was studied by disk diffusion test and assessment of minimum inhibitory concentration (MIC) using CLSI broth macrodilution method (M38-A2). Moreover, antileishmanial and cytotoxicity activity of B. vulgaris and berberine against promastigotes of Leishmania major and Leishmania tropica were evaluated by colorimetric MTT assay. The findings indicated that the various extracts of B. vulgaris particularly berberine showed high potential antidermatophytic against pathogenic dermatophytes tested with MIC values varying from 0.125 to >4 mg/mL. The results revealed that B. vulgaris extracts as well as berberine were effective in inhibiting L. major and L. tropica promastigotes growth in a dose-dependent manner with IC50 (50% inhibitory concentration) values varying from 2.1 to 26.6 μ g/mL. Moreover, it could be observed that berberine as compared with B. vulgaris exhibited more cytotoxicity against murine macrophages with CC50 (cytotoxicity concentration for 50% of cells) values varying from 27.3 to 362.6 μ g/mL. Results of this investigation were the first step in the search for new antidermatophytic and antileishmanial drugs. However, further works are required to evaluate exact effect of these extracts in animal models as well as volunteer human subjects.
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