Evidence map›Paper›PMID 24977000›Full record

ArticleJournal of thoracic disease2014

Levels of 1,25(OH)2D3 for patients with pulmonary tuberculosis and correlations of 1,25(OH)2D3 with the clinical features of TB.

Wei-Wei Gao, Yu Wang, Xiang-Rong Zhang, Chun-Yang Yin, Chun-Mei Hu, Man Tian, Hong-Wei Wang, Xia Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wei-Wei Gao1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
Yu Wang1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
Xiang-Rong Zhang1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
Chun-Yang Yin1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
Chun-Mei Hu1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
Man Tian1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
Hong-Wei Wang1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
Xia Zhang1 Department of Tuberculosis, Nanjing Chest Hospital, Nanjing 210029, China ; 2 Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China ; 3 Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] concentrations to patients with tuberculosis (TB) and whether it influenced the patient's clinical features.

methodsFor the first part, a total of 153 healthy adults and 74 patients with pulmonary TB (PTB) were enrolled. Serum concentrations of 1,25(OH)2D3 were determined by liquid chromatography-tandem mass spectroscopy to examine the 1,25(OH)2D3 concentrations of the two groups from the peripheral blood. If there are differences between the two groups, what follow will increase the experimental group numbers to examine the relationship among the 1,25(OH)2D3 concentrations with the numbers of the lesion area, the tubercule bacilli in sputum and the CD4/CD8 ratio of T lymphocytes in the peripheral blood.

resultsIn the first part, the 1,25(OH)2D3 concentrations was lower in patients with TB than in those healthy adults [365.9 (SD 235.7) vs. 464.3 (SD 335.6), P<0.05]. In the second part, we increased the sample size to 134 (male 91 cases, female 43 cases). we found that the plasma levels of 1,25(OH)2D3 are not correlated with the numbers of the lesion area and the tubercule bacilli in sputum, but the 1,25(OH)2D3 levels can interact the ratio of CD4/CD8 T lymphocytes, it shows a positive correlation with the ratio of CD4/CD8 T lymphocytes.

conclusionsThe 1,25(OH)2D3 concentrations in TB patients lower than the healthy adults, it might exist as a risk factor during the development of TB or TB might affect the levels of 1,25(OH)2D3. But the different status vitamin D concentration might not affect the numbers of the lesion area, the tubercule bacilli in sputum. It shows a positive correlation with the ratio of CD4/CD8 T lymphocytes. The study will have a significance value to clinical medicine, but further study will need to study the levels of 1,25(OH)2D3 with the TB.

Indexed as

1,25-dihydroxyvitamin D3 [1,25(OH)2D3]CD4/CD8 T lymphocytesclinical featuresTuberculosis (TB)

Identifiers

PMID24977000
PMCPMC4073399
OpenAlexW1701298233

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.