Evidence map›Paper›PMID 24976998›Full record

ArticleJournal of thoracic disease2014

A comparison of ketamine-midazolam and ketamine-propofol combinations used for sedation in the endobronchial ultrasound-guided transbronchial needle aspiration: a prospective, single-blind, randomized study.

Tülay Dal, Hilal Sazak, Mehtap Tunç, Saziye Sahin, Aydın Yılmaz

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02643979 phase4terminatednot on this mapstarted 2016, after this paper: background citation

Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2016 to 2019Enrolled22ConditionsObesity, Bariatrics, Sleep Apnea Syndromes, Gastric BypassArmsKetofol, Propofol, Saline
NCT02743104 nasuspendednot on this mapstarted 2016, after this paper: background citation

Ketamine vs Propofol for Sedation During Pediatric Bronchoscopy

TypeinterventionalSponsorRabin Medical CenterRan2016 to 2019Enrolled150ConditionsPaediatric Flexible BronchoscopyArmsKetamine, Propofol, midazolam and atropine, Lidocaine
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Clinical Effect and Safety Analysis of 2.5Journal of healthcare engineering · 2022
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  17. A Retrospective Analysis of Respiratory Complications under General Anesthesia during EBUS-TBNA.Journal of community hospital internal medicine perspectives · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tülay Dal1 Department of Anesthesiology and Reanimation, Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey ; 2 Department of Anesthesiology and Reanimation, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey ; 3 Gazi University, Faculty of Dentistry, Department of Anesthesiology, Ankara, Turkey ; 4 Department of Chest Diseases and Tuberculosis, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey.
Hilal Sazak1 Department of Anesthesiology and Reanimation, Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey ; 2 Department of Anesthesiology and Reanimation, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey ; 3 Gazi University, Faculty of Dentistry, Department of Anesthesiology, Ankara, Turkey ; 4 Department of Chest Diseases and Tuberculosis, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey.
Mehtap Tunç1 Department of Anesthesiology and Reanimation, Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey ; 2 Department of Anesthesiology and Reanimation, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey ; 3 Gazi University, Faculty of Dentistry, Department of Anesthesiology, Ankara, Turkey ; 4 Department of Chest Diseases and Tuberculosis, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey.
Saziye Sahin1 Department of Anesthesiology and Reanimation, Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey ; 2 Department of Anesthesiology and Reanimation, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey ; 3 Gazi University, Faculty of Dentistry, Department of Anesthesiology, Ankara, Turkey ; 4 Department of Chest Diseases and Tuberculosis, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey.
Aydın Yılmaz1 Department of Anesthesiology and Reanimation, Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, Turkey ; 2 Department of Anesthesiology and Reanimation, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey ; 3 Gazi University, Faculty of Dentistry, Department of Anesthesiology, Ankara, Turkey ; 4 Department of Chest Diseases and Tuberculosis, Ataturk Chest Disease and Thoracic Surgery Education and Research Hospital, Ankara, Turkey.
Türk Anesteziyoloji ve Reanimasyon Derneği · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to compare the effectiveness and safety of ketamine-midazolam and ketamine-propofol combinations for procedural sedation in endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA).

methodsSixty patients who were undergoing EBUS-TBNA were included in this study. Patients were randomly divided into two groups. Group 1 was given 0.25 mg/kg intravenous (iv) ketamine, 2 min later than 0.05 mg/kg iv midazolam. Group 2 received 0.125 mg/kg ketamine-propofol mixture (ketofol), 2 min subsequent to injection of 0.25 mg/kg each. Sedation was maintained with additional doses of ketamine 0.25 mg/kg, and ketofol 0.125 mg/kg each in Group 1 and Group 2, respectively. Blood pressure, heart rate (HR), peripheral oxygen saturation, respiratory rate (RR), Ramsay Sedation Score (RSS), and severity of cough were recorded prior to and after administration of sedation agent in the beginning of fiberoptic bronchoscopy (FOB) and every 5 min of the procedure. The consumption of the agents, the satisfactions of the bronchoscopist and the patients, and the recovery time were also recorded.

resultsHR in the 10(th) min and RSS value in the 35(th) min of induction in Group 1 were higher than the other group (P<0.05). The recovery time in Group 1 was statistically longer than Group 2 (P<0.05). There was no statistically significant difference between groups with respect to other parameters (P>0.05).

conclusionsIt was concluded that both ketamine-midazolam and ketamine-propofol combinations for sedation during EBUS-TBNA were similarly effective and safe without remarkable side effects.

Indexed as

ketaminemidazolampropofolsedationTransbronchial needle aspiration (TBNA)

Identifiers

PMID24976998
PMCPMC4073394
OpenAlexW2179062251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.