Evidence map›Paper›PMID 24976987›Full record

ArticleJournal of thoracic disease2014

Effect of pharmaceutical care on medication adherence and hospital admission in patients with chronic obstructive pulmonary disease (COPD): a randomized controlled study.

Li Wei, Xinyun Yang, Jie Li, Lianghui Liu, Hongying Luo, Zeguang Zheng, Yi Wei

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 10 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03607097 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Integral Management of Healthcare Problems Related With Drugs in Polimedicated Patients: Drug Code

TypeinterventionalSponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2018 to 2020Enrolled808ConditionsDrug Related Problems, Pharmaceutical CareArmsSecondary prevention program for drug related problems
NCT04841863 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Secondary Prevention of Dug-related Problems Through Patient Empowerment Through Digital Health

TypeinterventionalSponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2021 to 2023Enrolled200ConditionsDrug-Related ProblemsArmsMyPlan digital health platform, Satndard care
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 10 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  8. Pharmacist services for non-hospitalised patients.The Cochrane database of systematic reviews · 2018
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  10. Counseling for health behavior change in people with COPD: systematic review.International journal of chronic obstructive pulmonary disease · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Li Wei1 Pharmacy Department of First Affiliated Hospital, 2 Guangzhou Institute of Respiratory Disease of First Affiliated Hospital, 3 Pharmacology Department of Pharmaceutical College, Guangzhou Medical University, Guangzhou 510182, China.
Xinyun Yang1 Pharmacy Department of First Affiliated Hospital, 2 Guangzhou Institute of Respiratory Disease of First Affiliated Hospital, 3 Pharmacology Department of Pharmaceutical College, Guangzhou Medical University, Guangzhou 510182, China.
Jie Li1 Pharmacy Department of First Affiliated Hospital, 2 Guangzhou Institute of Respiratory Disease of First Affiliated Hospital, 3 Pharmacology Department of Pharmaceutical College, Guangzhou Medical University, Guangzhou 510182, China.
Lianghui Liu1 Pharmacy Department of First Affiliated Hospital, 2 Guangzhou Institute of Respiratory Disease of First Affiliated Hospital, 3 Pharmacology Department of Pharmaceutical College, Guangzhou Medical University, Guangzhou 510182, China.
Hongying Luo1 Pharmacy Department of First Affiliated Hospital, 2 Guangzhou Institute of Respiratory Disease of First Affiliated Hospital, 3 Pharmacology Department of Pharmaceutical College, Guangzhou Medical University, Guangzhou 510182, China.
Zeguang Zheng1 Pharmacy Department of First Affiliated Hospital, 2 Guangzhou Institute of Respiratory Disease of First Affiliated Hospital, 3 Pharmacology Department of Pharmaceutical College, Guangzhou Medical University, Guangzhou 510182, China.
Yi Wei1 Pharmacy Department of First Affiliated Hospital, 2 Guangzhou Institute of Respiratory Disease of First Affiliated Hospital, 3 Pharmacology Department of Pharmaceutical College, Guangzhou Medical University, Guangzhou 510182, China.
First Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor adherence leads to a high rate of exacerbation and poor health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD). However, few strategies are acceptable and effective in improving medication adherence. We investigated whether pharmaceutical care by clinical pharmacists could reinforce medication adherence to reduce exacerbation and improve HRQoL.

methodsA randomized controlled study was carried out at The First Affiliated Hospital of Guangzhou Medical University from February 2012 to January 2014. Non-adherence patients were randomly assigned to receive pharmaceutical care or to usual care. The pharmaceutical care consisted of individualized education and a series of telephone counseling for 6 months provided by clinical pharmacists. Medication adherence was measured by pill counts plus direct interview at 1- and 6-month pharmaceutical care and one-year follow-up. Severe exacerbations were defined as events that led to hospitalization for acute COPD attack. An interview was conducted to investigate hospital admissions and evaluate severe exacerbations at one-year follow-up. HRQoL was measured by St George's Respiratory Questionnaire at 6 months.

resultsAt 6-month pharmaceutical care and one-year follow-up, the pharmaceutical care group exhibited higher medication adherence than the usual care group (73.4±11.1 vs. 55.7±11.9, P=0.016 and 54.4±12.5 vs. 66.5±8.6, P=0.039, respectively). There are 60 acute exacerbations resulted in a hospital admission in the usual group while 37 ones in the pharmaceutical care group during one-year follow-up (P=0.01). Hospital admissions due to acute exacerbation in the pharmaceutical care group were 56.3% less than the usual care group (P=0.01). There was a significant difference in the symptoms and impact subscales respectively at 6-month pharmaceutical care between two groups (P=0.032, P=0.018).

conclusionsIndividualized pharmaceutical care improved medication adherence, reduced hospitalization and elevated HRQoL in patients with COPD.

Indexed as

chronic obstructive pulmonary disease (COPD)hospitalizationmedication adherencePharmaceutical care

Identifiers

PMID24976987
PMCPMC4073386
OpenAlexW2104730988

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.