Evidence map›Paper›PMID 24976847›Full record

ArticleDrug discovery today. Disease models2011

Metalloproteinases in hypertension and cardiac disease: differential expression and mutual regulation.

Ana-Maria Bosonea, Xiang Wang, Jeffrey Odenbach, Carlos Fernandez-Patron

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug discovery today. Disease models, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ana-Maria BosoneaDepartment of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada ; The Cardiovascular Research Group, University of Alberta, Edmonton, AB, Canada.
Xiang WangDepartment of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada ; The Cardiovascular Research Group, University of Alberta, Edmonton, AB, Canada.
Jeffrey OdenbachDepartment of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada ; The Cardiovascular Research Group, University of Alberta, Edmonton, AB, Canada.
Carlos Fernandez-PatronDepartment of Biochemistry, School of Molecular and Systems Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada ; The Cardiovascular Research Group, University of Alberta, Edmonton, AB, Canada ; Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CA

Funding

CIHR 106580-1PHS HHS 106580-1
6 · The paper itself

Abstract

Arterial hypertension, a condition characterized by sustained elevated blood pressure, is associated with pathological cardiac remodeling (i.e. cardiac hypertrophy and fibrosis) and is a major risk factor for cardiac failure. These processes can be triggered by excess vasoconstrictive agonists, which induce metalloproteinase-dependent shedding of growth factors to transactivate growth factor receptors and initiate disease signaling. Here, we review emerging evidence that agonist-activated metalloproteinases exhibit different expression patterns and mutual transcriptional regulation during the development of hypertension and cardiac remodeling.

Identifiers

PMID24976847
PMCPMC4071041
OpenAlexW2139569901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.