ArticleHepatitis monthly2014
Efficacy and safety of ferric chloride in controlling hepatic bleeding; an animal model study.
Article in Hepatitis monthly, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- The Advantages and Disadvantages of Methods Used to Control Liver Bleeding: A Review.Trauma monthly · 2015Review
- Efficacy and safety of aluminum chloride in controlling external hemorrhage: an animal model study.Iranian Red Crescent medical journal · 2015Article
- Use of ferric sulfate to control hepatic bleeding.Trauma monthly · 2015Article
- Investigating the effect of zinc chloride to control external bleeding in rats.Nursing and midwifery studies · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundControlling parenchymal hemorrhage especially in liver parenchyma, despite all the progress in surgical science, is still one of the challenges surgeons face saving patients' lives and there is a research challenge among researchers in this field to introduce a more effective method.
objectivesThis study attempts to determine the haemostatic effect of ferric chloride and compare it with that of the standard method (suturing technique) in controlling bleeding from liver parenchymal tissue. MATERIALS AND
methodsIn this animal model study 60 male Wistar rats were used. An incision, two centimeters (cm) long and half a cm deep, was made on each rat's liver and the hemostasis time was measured once using ferric chloride with different concentrations (5%, 10%, 15%, 25% and 50%) and then using the control method (i.e. controlling bleeding by suturing). The liver tissue was examined for pathological changes.
resultsThe hemostasis time of ferric chloride concentration groups was significantly less than that of the control group (P value < 0.001). The pathologic examination showed the highest frequency of low grade inflammation based on the defined pathological grading.
conclusionsFerric chloride is an effective haemostatic agent in controlling liver parenchymal tissue hemorrhage in an animal model.
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Registered trials
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