ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2014
Chronic non-social stress affects depressive behaviors but not anxiety in mice.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Pre-treatment with royal jelly, environmental enrichment, and their combination role in stress induced neurobehavioral deficits in male rats.IBRO neuroscience reports · 2026Article
- Pharmacological investigation of oxadiazole derivatives in Alzheimer's disease: Modulation of oxidative stress, neuroinflammation, and iNOS signaling.Iranian journal of basic medical sciences · 2026Article
- Chronic Unpredictable Stress Impairs Social Behaviour in Adult Male Rats: Correlations with Dopamine and Serotonin Levels.Molecular neurobiology · 2025Article
- Regulating the NMDA/NR2B signaling pathway mediates anticonvulsant, antineuroinflammation, and anti-oxidative stress effects of 1,3,benzothiazole derivative 1M in pentylenetetrazole-induced kindling in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus.Inflammopharmacology · 2022Article
- A Glimpse Into the Sexual Dimorphisms in Major Depressive Disorder Through Epigenetic Studies.Frontiers in neural circuits · 2021Review
- Paternal transgenerational epigenetic mechanisms mediating stress phenotypes of offspring.The European journal of neuroscience · 2021Review
- Agomelatine Softens Depressive-Like Behavior through the Regulation of Autophagy and Apoptosis.BioMed research international · 2021Article
- Behavioral and Oxidative Stress Changes in Mice Subjected to Combinations of Multiple Stressors Relevant to Irritable Bowel Syndrome.Brain sciences · 2020Article
- The effect of depressive-like behavior and antidepressant therapy on social behavior and hierarchy in rats.Behavioural brain research · 2019Article
- The Antidepressant-like Effect of Flavonoids fromMolecules (Basel, Switzerland) · 2019Article
- miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior.Neuropharmacology · 2019Article
- Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice.BMC neuroscience · 2018Article
- Effect of chronic unpredictable stress on mice with developmental under-expression of the Ahi1 gene: behavioral manifestations and neurobiological correlates.Translational psychiatry · 2018Article
- On the Developmental Timing of Stress: Delineating Sex-Specific Effects of Stress across Development on Adult Behavior.Brain sciences · 2018Review
- Stress does not increase blood-brain barrier permeability in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Emotional Stress and Cardiovascular Complications in Animal Models: A Review of the Influence of Stress Type.Frontiers in physiology · 2016Review
- Possible Involvement of µ Opioid Receptor in the Antidepressant-Like Effect of Shuyu Formula in Restraint Stress-Induced Depression-Like Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Chronic subordinate colony housing paradigm: a mouse model to characterize the consequences of insufficient glucocorticoid signaling.Frontiers in psychiatry · 2015Review
- Alterations of amino Acid level in depressed rat brain.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2014Article
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4 authors.
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Abstract
The etiology of most psychiatric disorders is still incompletely understood. However, growing evidence suggests that stress is a potent environmental risk factor for depression and anxiety. In rodents, various stress paradigms have been developed, but psychosocial stress paradigms have received more attention than non-social stress paradigms because psychosocial stress is more prevalent in humans. Interestingly, some recent studies suggest that chronic psychosocial stress and social isolation affects mainly anxiety-related behaviors in mice. However, it is unclear whether chronic non-social stress induces both depression- and anxiety-related phenotypes or induces one specific phenotype in mice. In the present study, we examined the behavioral consequences of three chronic non-social stress paradigms: chronic predictable (restraint) stress (CPS), chronic unpredictable stress (CUS), and repeated corticosterone-HBC complex injection (RCI). Each of the three paradigms induced mild to severe depression/despair-like behaviors in mice and resulted in increased immobility in a tail suspension test. However, anxiety-related phenotypes, thigmotaxis and explorative behaviors, were not changed by the three paradigms. These results suggest that depression- and anxiety-related phenotypes can be dissociated in mouse stress models and that social and non-social stressors might affect brain circuits and behaviors differently.
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