ReviewWorld journal of gastroenterology2014
Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome.
Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 54 citations in OpenAlex.
- Effects of Patients' Affect on Adverse Procedural Events during Image-Guided Interventions.Journal of vascular and interventional radiology : JVIR · 2017Trial
- Ehealth: low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome.World journal of gastroenterology · 2014Trial
- Paradigm Shift of Microbiota-gut-brain Axis During Aging: Potential Role of Probiotics to Improve Cognitive Decline.Probiotics and antimicrobial proteins · 2026Review
- Coping with the burden of irritable bowel syndrome by emotional suppression-A cross sectional observational pilot study.Journal of general and family medicine · 2025Article
- Breaking the cycle: Psychological and social dimensions of pediatric functional gastrointestinal disorders.World journal of clinical pediatrics · 2025Article
- The Relationship between Canine Behavioral Disorders and Gut Microbiome and Future Therapeutic Perspectives.Animals : an open access journal from MDPI · 2024Review
- Integrated Approaches in the Management of Gastrointestinal Disorders: A Biopsychosocial Perspective.Cureus · 2024Review
- Gut feelings: associations of emotions and emotion regulation with the gut microbiome in women.Psychological medicine · 2023Article
- Supraspinal Mechanisms of Intestinal Hypersensitivity.Cellular and molecular neurobiology · 2022Review
- Self-Reported Impaired Wound Healing in Young Adults and Their Susceptibility to Experiencing Immune-Related Complaints.Journal of clinical medicine · 2022Article
- A Resting-state Functional Magnetic Resonance Imaging Study of Whole-brain Functional Connectivity of Voxel Levels in Patients With Irritable Bowel Syndrome With Depressive Symptoms.Journal of neurogastroenterology and motility · 2021Article
- Spine and TMJ: A Pathophysiology Report.Journal of functional morphology and kinesiology · 2020Article
- Postprandial Symptoms in Patients With Functional Dyspepsia and Irritable Bowel Syndrome: Relations to Ultrasound Measurements and Psychological Factors.Journal of neurogastroenterology and motility · 2020Article
- Oral Health and Fibromyalgia Syndrome: A Systemic Review.Journal of functional morphology and kinesiology · 2020Review
- Moxidectin Effects on Gut Microbiota of Wistar-Kyoto Rats: Relevance to Depressive-Like Behavior.Clinical pharmacology and translational medicine · 2019Article
- Review
- Conditions Associated with Essential Tremor in Veterans: A Potential Role for Chronic Stress.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- Gut microbiota's effect on mental health: The gut-brain axis.Clinics and practice · 2017Article
- Does depression increase the risk of stroke in patients with rheumatoid arthritis? A population-based cohort study.BMJ open · 2017Article
- Role of stem cell growth factor/c-Kit in the pathogenesis of irritable bowel syndrome.Experimental and therapeutic medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irritable bowel syndrome (IBS) is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major role. The biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors, interacting with peripheral/central neuroendocrine and immune changes, may induce symptoms of IBS, modulate symptom severity, influence illness experience and quality of life, and affect outcome. The present review focuses on the role of negative affects, including depression, anxiety, and anger, on pathogenesis and clinical expression of IBS. The potential role of the autonomic nervous system, stress-hormone system, and immune system in the pathophysiology of both negative affects and IBS are taken into account. Psychiatric comorbidity and subclinical variations in levels of depression, anxiety, and anger are further discussed in relation to the main pathophysiological and symptomatic correlates of IBS, such as sensorimotor functions, gut microbiota, inflammation/immunity, and symptom reporting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.