ArticleBrain research2014
Egr-1 mRNA expression patterns in the prefrontal cortex, hippocampus, and amygdala during variants of contextual fear conditioning in adolescent rats.
Article in Brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Alcohol and fear conditioning produce strain-specific changes in the dorsal hippocampal transcriptome of adolescent C57BL/6J and DBA/2J mice.Alcohol, clinical & experimental research · 2024Article
- Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats.Neurobiology of learning and memory · 2019Article
- Differential involvement of amygdalar NMDA receptors across variants of contextual fear conditioning in adolescent rats.Behavioural brain research · 2019Article
- Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.Behavioral neuroscience · 2018Article
- Contextual fear retrieval-induced Fos expression across early development in the rat: An analysis using established nervous system nomenclature ontology.Neurobiology of learning and memory · 2018Article
- Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Differential expression of the immediate early genes c-Fos, Arc, Egr-1, and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Antagonism of muscarinic acetylcholine receptors in medial prefrontal cortex disrupts the context preexposure facilitation effect.Neurobiology of learning and memory · 2017Article
- Differential involvement of the medial prefrontal cortex across variants of contextual fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Understanding the contributions of visual stimuli to contextual fear conditioning: A proof-of-concept study using LCD screens.Neuroscience letters · 2017Article
- Corticotropin releasing factor type-1 receptor antagonism in the dorsolateral bed nucleus of the stria terminalis disrupts contextually conditioned fear, but not unconditioned fear to a predator odor.Psychoneuroendocrinology · 2016Article
- Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.Behavioral neuroscience · 2016Article
- Limbic system development underlies the emergence of classical fear conditioning during the third and fourth weeks of life in the rat.Behavioral neuroscience · 2016Article
- Variants of contextual fear conditioning induce differential patterns of Egr-1 activity within the young adult prefrontal cortex.Behavioural brain research · 2016Article
- NMDA receptor antagonism disrupts acquisition and retention of the context preexposure facilitation effect in adolescent rats.Behavioural brain research · 2016Article
- Developmental emergence of fear/threat learning: neurobiology, associations and timing.Genes, brain, and behavior · 2016Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We report activation of the immediate-early gene Egr-1 in the lateral amygdala (LA), hippocampus (CA1), and medial prefrontal cortex (mPFC) 30-min following the training phase in the context pre-exposure facilitation effect (CPFE) and standard context fear conditioning (180 s context exposure→shock). On day one of the CPFE paradigm, postnatal day (PD) 31 rats (±1) were pre-exposed to Context A (Pre) or Context B (Alt-Pre) for 5 min followed by five additional 1-min exposures. A day later, Pre and Alt-Pre rats received a 2-s, 1.5 mA footshock immediately upon placement in Context A. Animals included in in situ hybridization were then sacrificed 30 (±3) min later. On day three, the behaviorally-tested Pre rats showed significantly more fear-conditioned freezing in Context A than Alt-Pre rats. Standard context fear conditioning groups showed much greater freezing than the Pre group, as well as no shock and immediate-shock controls. Thirty minutes after immediate shock training, Pre rats showed increased Egr-1 mRNA in the prelimbic mPFC relative to Alt-Pre rats. Standard context conditioning selectively increased Egr-1 in CA1. In the LA and mPFC, Egr-1 increased to a similar extent in no shock, immediate shock, and standard context conditioning relative to homecage controls. The present study demonstrates that Egr-1 mRNA expression has a complex relationship to fear learning in different brain regions and variants of context conditioning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.