ArticleHuman brain mapping2014
Impaired development of intrinsic connectivity networks in children with medically intractable localization-related epilepsy.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 68 citations in OpenAlex.
- Directed graph neural networks with partial directed coherence for seizure prediction and epileptogenic network characterization.iScience · 2026Article
- Language Dysfunction Associated with Pathological Brain Connectivity in Children with Epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Imaging brain development in a KCNQ2-developmental and epileptic encephalopathy mouse model: identifying early biomarkers for functional and structural brain changes.EBioMedicine · 2025Article
- Abnormalities of thalamus and thalamocortical pathways in patients with refractory epilepsy caused by focal cortical dysplasia - MRI study.Epilepsia open · 2025Article
- Whole-brain white matter variation across childhood environments.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Editorial: Advances in epilepsy research: exploring biomarkers, brain stimulation, and neurosurgical interventions.Frontiers in human neuroscience · 2025Article
- Alterations of apparent diffusion coefficient from ultra high b-values in the bilateral thalamus and striatum in MRI-negative drug-resistant epilepsy.Epilepsia open · 2024Article
- Postoperative cerebellar mutism syndrome is an acquired autism-like network disturbance.Neuro-oncology · 2024Article
- Learning site-invariant features of connectomes to harmonize complex network measures.Proceedings of SPIE--the International Society for Optical Engineering · 2024Article
- Resting-state functional MRI study of conventional MRI-negative intractable epilepsy in children.Frontiers in human neuroscience · 2024Article
- Interconnected Pathways: Postural Stability and Vocabulary Skills in Preschool-Aged Children.Children (Basel, Switzerland) · 2023Article
- Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Real-time motion monitoring improves functional MRI data quality in infants.Developmental cognitive neuroscience · 2022Article
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- Social brain networks: Resting-state and task-based connectivity in youth with and without epilepsy.Neuropsychologia · 2021Article
- An exploratory study into the influence of laterality and location of hippocampal sclerosis on seizure prognosis and global cortical thinning.Scientific reports · 2021Article
- The neural basis of executive functioning deficits in adolescents with epilepsy: a resting-state fMRI connectivity study of working memory.Brain imaging and behavior · 2021Article
- Lesion Network Localization of Seizure Freedom following MR-guided Laser Interstitial Thermal Ablation.Scientific reports · 2019Article
- Alteration of the anatomical covariance network after corpus callosotomy in pediatric intractable epilepsy.PloS one · 2019Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Typical childhood development is characterized by the emergence of intrinsic connectivity networks (ICNs) by way of internetwork segregation and intranetwork integration. The impact of childhood epilepsy on the maturation of ICNs is, however, poorly understood. The developmental trajectory of ICNs in 26 children (8-17 years) with localization-related epilepsy and 28 propensity-score matched controls was evaluated using graph theoretical analysis of whole brain connectomes from resting-state functional magnetic resonance imaging (fMRI) data. Children with epilepsy demonstrated impaired development of regional hubs in nodes of the salience and default mode networks (DMN). Seed-based connectivity and hierarchical clustering analysis revealed significantly decreased intranetwork connections, and greater internetwork connectivity in children with epilepsy compared to controls. Significant interactions were identified between epilepsy duration and the expected developmental trajectory of ICNs, indicating that prolonged epilepsy may cause progressive alternations in large-scale networks throughout childhood. DMN integration was also associated with better working memory, whereas internetwork segregation was associated with higher full-scale intelligence quotient scores. Furthermore, subgroup analyses revealed the thalamus, hippocampus, and caudate were weaker hubs in children with secondarily generalized seizures, relative to other patient subgroups. Our findings underscore that epilepsy interferes with the developmental trajectory of brain networks underlying cognition, providing evidence supporting the early treatment of affected children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.