ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Opioid use is associated with decreased quality of life in patients with Crohn's disease.
Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The Relationship Between Opioid Use and Healthcare Utilization in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Inflammatory bowel diseases · 2022Pooled it
- Latent profiles of fatigue in inflammatory bowel disease.BMC gastroenterology · 2024Article
- Irritable Bowel Syndrome Is an Independent Risk Factor for Developing Opioid Use Disorder in Patients with Inflammatory Bowel Disease.Journal of personalized medicine · 2023Article
- Examining the influence of inflammatory bowel disease medications on sleep quality.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
- Substance Use Among Patients With Incident Crohn's Disease in the United States, 2010 to 2019: A Medicaid Observational Study.Gastro hep advances · 2023Article
- Short-Term and Long-Term Opioid Use Is Associated With Poor Outcomes in Outpatients With Inflammatory Bowel Disease.Gastro hep advances · 2023Article
- Trends in hospital admissions and mortality among inflammatory bowel disease patients with substance use disorder: a 10-year United States nationwide analysis.Proceedings (Baylor University. Medical Center) · 2023Article
- Opioid Use Associated With Higher Costs Among Patients With Inflammatory Bowel Disease.Crohn's & colitis 360 · 2021Article
- Chronic opioid use is associated with early biologic discontinuation in inflammatory bowel disease.Alimentary pharmacology & therapeutics · 2021Article
- Current overview of opioids in progression of inflammatory bowel disease; pharmacological and clinical considerations.Molecular biology reports · 2021Review
- Opioid Analgesics Do Not Improve Abdominal Pain or Quality of Life in Crohn's Disease.Digestive diseases and sciences · 2020Article
- Implications of the Opioid Epidemic for the Clinical Gastroenterology Practice.Current gastroenterology reports · 2019Review
- Assessing mental health and the relation with variables of demographic and clinical in Crohn's disease patients; 2016-2017.Journal of family medicine and primary care · 2019Article
- Utilization of pain medications and its effect on quality of life, health care utilization and associated costs in individuals with chronic back pain.Journal of pain research · 2019Article
- The Association Between Sustained Poor Quality of Life and Future Opioid Use in Inflammatory Bowel Disease.Inflammatory bowel diseases · 2018Article
- Opioid Medications in the Management of Chronic Abdominal Pain.Current pain and headache reports · 2017Review
- Predicting Costs of Care for Patients With Inflammatory Bowel Diseases.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Article
- Vedolizumab Therapy Is Associated with an Improvement in Sleep Quality and Mood in Inflammatory Bowel Diseases.Digestive diseases and sciences · 2017Observational
- Alcohol and narcotics use in inflammatory bowel disease.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsQuality of life is an important consideration in the management of patients with Crohn's disease. Previous studies suggest that Crohn's disease patients using opioids may have decreased quality of life and increased risk of mortality. Our aim was to determine the association between health-related quality of life (HRQoL) and opioid use in patients with Crohn's disease while controlling for disease severity. PATIENTS AND
methodsWe conducted a cross-sectional study recruiting Crohn's disease patients at our center. Disease activity was measured using the Harvey-Bradshaw Index (HBI), and HRQoL was measured using the Inflammatory Bowel Disease Questionnaire (IBDQ).
resultsWe enrolled 38 Crohn's disease patients using opioids and 62 patients not using opioids. Patients using opioids had an increased duration of disease (median 18.5 vs. 9 years, P = 0.005), increased surgeries related to Crohn's disease (median 3 vs. 0, P < 0.001), and increased prednisone use (29% vs. 11.3%, P = 0.03). Patients using opioids had increased disease activity (median HBI score 9.0 vs. 3.0, P < 0.001). Quality of life was lower in patients using opioids (mean IBDQ score 109.3 vs. 162.9, P < 0.001). This finding was significant when controlling for HBI scores, number of previous surgeries, and prednisone use (P = 0.003).
conclusionsOpioid use in Crohn's disease patients appears to be associated with disease activity and severity. HRQoL is markedly decreased in patients using opioids and this association is significant even when controlling for variables reflecting disease severity. Our findings suggest that Crohn's disease patients using opioids are likely to be significantly impacted by their disease.
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