ArticleAmerican journal of human genetics2014
Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations.
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Article in American journal of human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 8 of them syntheses that pooled it.
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49citing papers in PubMed, 8 pooled it
8.4field-weighted citation impact, top 2% of its field
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Who cites it
49 citing papers in PubMed, 8 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.Nature genetics · 2025Pooled it
- A large genome-wide association study of QT interval length utilizing electronic health records.Genetics · 2022Pooled it
- Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2022Pooled it
- Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2018Guideline
- Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.Circulation. Cardiovascular genetics · 2017Pooled it
- The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.Nature genetics · 2016Pooled it
- Rare Exome Sequence Variants in CLCN6 Reduce Blood Pressure Levels and Hypertension Risk.Circulation. Cardiovascular genetics · 2016Pooled it
- Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension.American journal of human genetics · 2015Pooled it
- A simple approach for multiple observations improves power to detect genetic effects and genomic prediction accuracy.HGG advances · 2026Article
- Cysteine-rich intestinal protein family: structural overview, functional diversity, and roles in human disease.Cell death discovery · 2025Review
- The PRIMED Consortium: Reducing disparities in polygenic risk assessment.American journal of human genetics · 2024Article
- Disentangling the phenotypic patterns of hypertension and chronic hypotension.Journal of biomedical informatics · 2024Article
- Genetic variation in CCDC93 is associated with elevated central systolic blood pressure, impaired arterial relaxation, and mitochondrial dysfunction.PLoS genetics · 2024Article
- Sex-specific genetic architecture of blood pressure.Nature medicine · 2024Article
- Causal relationships between blood lipids and major psychiatric disorders: Univariable and multivariable mendelian randomization analysis.BMC medical genomics · 2023Article
- Knowledgebase strategies to aid interpretation of clinical correlation research.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Intrinsic Adrenal TWIK-Related Acid-Sensitive TASK Channel Dysfunction Produces Spontaneous Calcium Oscillations Sufficient to Drive AngII (Angiotensin II)-Unresponsive Hyperaldosteronism.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Optimizing Genetic Analyses of Serum Lipids in Longitudinal Data.Circulation research · 2020Article
- Association of Established Blood Pressure Loci With 10-Year Change in Blood Pressure and Their Ability to Predict Incident Hypertension.Journal of the American Heart Association · 2020Article
- TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.American journal of physiology. Heart and circulatory physiology · 2020Article
Corrections and comments
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Authors and funding
55 authors at 20 institutions in 6 countries.
Santhi K GaneshDepartments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: sganesh@umich.edu.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston MA, 02115, USA.
Martin G LarsonFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Department of Mathematics, Boston University, Boston, MA 02215, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Germain VerwoertDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Xiangjun GuResearch Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Albert V SmithIcelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
Min-Lee YangDepartments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Yan ZhangDepartment of Cardiology, Peking University First Hospital, Beijing 100034, China.
Georg EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns-Hopkins University School of Medicine, Baltimore, MD 21205, USA; Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospitals, 1211 Geneva, Switzerland.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Shih-Jen HwangFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
George J PapanicolauDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA.
Eric J SijbrandsDepartment of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Gudny EiriksdottirIcelandic Heart Association, 201 Kopavogur, Iceland.
Vasyl PihurCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns-Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston MA, 02115, USA.
Ramachandran S VasanFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Divisions of Epidemiology and Cardiology, Department of Medicine, Boston University School for Medicine, Boston, MA 02118, USA.
Christopher Newton-ChehCardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.
Global Blood Pressure Genetics Consortium
Leslie J RaffelMedical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Kiang LiuDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD 20892, USA.
Ming XuDepartment of Cardiology, Peking University Third Hospital, Beijing 100191, China.
Mark CaulfieldClinical Pharmacology and the Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
Alanna C MorrisonHuman Genetics Center, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
Andrew D JohnsonFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 02892, USA.
Dhananjay VaidyaDepartment of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
Guo LiCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Tamara B HarrisLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD 20892, USA.
He ZhangDepartments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Eric BoerwinkleHuman Genetics Center, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
David S SiscovickCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA.
Wei GaoDepartment of Cardiology, Peking University Third Hospital, Beijing 100191, China.
Andre G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, 2593 the Hague, the Netherlands.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
Cristen J WillerDepartments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
Yong HuoDepartment of Cardiology, Peking University First Hospital, Beijing 100034, China.
Jacqueline C M WittemanDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands.
Patricia B MunroeClinical Pharmacology and the Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
Vilmundur GudnasonIcelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
Walter PalmasDepartment of Medicine, Columbia University, New York, NY 10032, USA.
Cornelia van DuijnDepartment of Epidemiology, Erasmus University Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, the Netherlands; Netherlands Consortium for Healthy Aging, Netherlands Genomics Initiative, 2593 the Hague, the Netherlands; Centre for Medical Systems Biology, Netherlands Genomics Initiative, 2593 the Hague, the Netherlands.
Myriam FornageResearch Center for Human Genetics, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Daniel LevyFramingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA; Boston University School of Medicine, Boston, MA 02118, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98101, USA.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns-Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aravinda@jhmi.edu.
Erasmus MC · NLUniversity of Washington · USUniversity of Michigan · USNational Heart Lung and Blood Institute · USPeking University · CNJohns Hopkins University · USQueen Mary University of London · GBThe University of Texas Health Science Center at Houston · USBrigham and Women's Hospital · USBoston University · USNational Institute on Aging · USMassachusetts General Hospital · USCedars-Sinai Medical Center · USCenter for Human Genetics · USColumbia University · USGroup Health Cooperative · USIcelandic Heart Association · ISNorthwestern University · USPennington Biomedical Research Center · USThe Lundquist Institute · US
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MFramingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MCardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1MCancer Research UK 14136Medical Research Council G0401527Medical Research Council G1000143Medical Research Council G9521010Medical Research Council MR/K006584/1NCATS NIH HHS UL1 TR000124NHLBI NIH HHS R01 HL105756NIDDK NIH HHS P30 DK063491
Abstract
Blood pressure (BP) is a heritable, quantitative trait with intraindividual variability and susceptibility to measurement error. Genetic studies of BP generally use single-visit measurements and thus cannot remove variability occurring over months or years. We leveraged the idea that averaging BP measured across time would improve phenotypic accuracy and thereby increase statistical power to detect genetic associations. We studied systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP) averaged over multiple years in 46,629 individuals of European ancestry. We identified 39 trait-variant associations across 19 independent loci (p < 5 × 10(-8)); five associations (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23 (rs1275988, near KCNK3), DBP at 2q11.2 (rs7599598, in FER1L5), and PP at 6p21 (rs10948071, near CRIP3) and 7p13 (rs2949837, near IGFBP3). Replication analyses conducted in cohorts with single-visit BP data showed positive replication of associations and a nominal association (p < 0.05). We estimated a 20% gain in statistical power with long-term average (LTA) as compared to single-visit BP association studies. Using LTA analysis, we identified genetic loci influencing BP. LTA might be one way of increasing the power of genetic associations for continuous traits in extant samples for other phenotypes that are measured serially over time.
Indexed as
Quantitative Trait LociBlood PressureGenome-Wide Association StudyHumansLongitudinal StudiesPhenotypePolymorphism, Single Nucleotide
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