ArticleSynapse (New York, N.Y.)2014
Adolescent bisphenol-A exposure decreases dendritic spine density: role of sex and age.
Article in Synapse (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Potential association between endocrine disrupting chemicals (EDCs) and gynecomastia: a systematic review based on partial experimental evidenceendocrine-disrupting chemicals.Frontiers in endocrinology · 2026Pooled it
- Neurotoxic Effects of Bisphenol (BPA): Mini-Reviews.Toxics · 2025Review
- Article
- Potential neuroprotective effect of nanomicellar curcumin on learning and memory functions following subacute exposure to bisphenol A in adult male rats.Metabolic brain disease · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Impact of a bisphenol A, F, and S mixture and maternal care on the brain transcriptome of rat dams and pups.Neurotoxicology · 2022Article
- Sex differences in cognition following variations in endocrine status.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Review
- The Sexual Dimorphic Synapse: From Spine Density to Molecular Composition.Frontiers in molecular neuroscience · 2022Review
- Adult Male Rats Show Resilience to Adolescent Bisphenol A Effects on Hormonal and Behavioral Responses While Co-Exposure With Hop Extracts Supports Synergistic Actions.Frontiers in toxicology · 2021Article
- Estrogenic regulation of memory: The first 50 years.Hormones and behavior · 2020Review
- Structural plasticity of the hippocampus in response to estrogens in female rodents.Molecular brain · 2019Review
- Loss of Hippocampal Oligodendrocytes Contributes to the Deficit of Contextual Fear Learning in Adult Rats Experiencing Early Bisphenol A Exposure.Molecular neurobiology · 2017Article
- Bisphenol A Impairs Synaptic Plasticity by Both Pre- and Postsynaptic Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
- Effects of Water Bottle Materials and Filtration on Bisphenol A Content in Laboratory Animal Drinking Water.Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Article
- The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation.Neural plasticity · 2017Article
- This can't be stressed enough: The contribution of select environmental toxicants to disruption of the stress circuitry and response.Physiology & behavior · 2016Review
- Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study.Hormones and behavior · 2016Article
- The evolving role of dendritic spines and memory: Interaction(s) with estradiol.Hormones and behavior · 2015Review
- Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats.Hormones and behavior · 2015Article
- The effects of postnatal exposure to low-dose bisphenol-A on activity-dependent plasticity in the mouse sensory cortex.Frontiers in neuroanatomy · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Bisphenol-A (BPA), a common environmental endocrine disruptor, modulates estrogenic, androgenic, and antiandrogenic effects throughout the lifespan. We recently showed that low dose BPA exposure during adolescence increases anxiety and impairs spatial memory independent of sex. In this study, six week old Sprague Dawley rats (n=24 males, n=24 females) received daily subcutaneous injections (40 µg/kg bodyweight) of BPA or vehicle for one week. Serum corticosterone levels in response to a 1 h restraint stress and spine density were examined at age 7 (cohort 1) and 11 (cohort 2) weeks. Adolescent BPA exposure did not alter stress dependent corticosterone responses but decreased spine density on apical and basal dendrites of pyramidal cells in the medial prefrontal cortex (mPFC) and hippocampal CA1 region (CA1). Sex differences in spine density were observed on basal dendrites of the mPFC and CA1 with females having greater spine density than males. This sex difference was further augmented by both age and treatment, with results indicating that BPA-dependent decreases in spine density were more pronounced in males than females on mPFC basal dendrites. Importantly, the robust neuronal alterations were observed in animals exposed to BPA levels below the current U.S.E.P.A. recommended safe daily limit. These results are the first demonstrating that BPA given during adolescence leads to enduring effects on neural morphology at adulthood. Given that humans are routinely exposed to low levels of BPA through a variety of sources, the decreased spine density reported in both male and female rats after BPA exposure warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.