ArticleMolecular microbiology2014
Magnesium-dependent processes are targets of bacterial manganese toxicity.
Article in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Microbial metal physiology: ions to ecosystems.Nature reviews. Microbiology · 2025Review
- Forging biofilms: metal-induced microbial responses in biofilm formation.Journal of bacteriology · 2025Review
- Manganese and phosphate removal from culture medium during the growth of the bacterium Sphaerotilus montanus.Folia microbiologica · 2025Article
- Disruption of zinc homeostasis reverses tigecycline resistance inFrontiers in cellular and infection microbiology · 2025Article
- The mntH gene of Burkholderia cenocepacia influences motility and quorum sensing to control virulence.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Metalation of Extracytoplasmic Proteins and Bacterial Cell Envelope Homeostasis.Annual review of microbiology · 2024Review
- Biosorption of copper, nickel, and manganese as well as the production of metal nanoparticles by Bacillus species isolated from soils contaminated with electronic wastes.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- TheJournal of bacteriology · 2024Article
- Metalloproteomic analysis of liver proteins isolated from broilers fed with different sources and levels of copper and manganese.Scientific reports · 2024Article
- ThebioRxiv : the preprint server for biology · 2024Article
- Structures and coordination chemistry of transporters involved in manganese and iron homeostasis.Biochemical Society transactions · 2023Review
- Manganese Transporter Proteins in Salmonella enterica serovar Typhimurium.Journal of microbiology (Seoul, Korea) · 2023Review
- Iron homeostasis inMicrobiology (Reading, England) · 2023Article
- Bioinformatics and Genomic Analyses of the Suitability of Eight Riboswitches for Antibacterial Drug Targets.Antibiotics (Basel, Switzerland) · 2022Article
- Nramp: Deprive and conquer?Frontiers in cell and developmental biology · 2022Article
- Regulation of Bacterial Manganese Homeostasis and Usage During Stress Responses and Pathogenesis.Frontiers in molecular biosciences · 2022Review
- Interchangeable utilization of metals: New perspectives on the impacts of metal ions employed in ancient and extant biomolecules.The Journal of biological chemistry · 2021Review
- Article
- Manganese impairs the QoxABCD terminal oxidase leading to respiration-associated toxicity.Molecular microbiology · 2021Article
- Open simultaneous saccharification and fermentation of l-lactic acid by complete utilization of sweet sorghum stalk: a water-saving process.RSC advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A Bradyrhizobium japonicum mutant defective in the gene encoding the high-affinity Mn(2+) transporter MntH has a severe growth phenotype under manganese limitation. Here, we isolated suppressor mutants of an mntH strain that grew under manganese limitation, and activities of high-affinity Mn(2+) transport and Mn(2+) -dependent enzymes were partially rescued. The suppressor strains harbour gain-of-function mutations in the gene encoding the Mg(2+) channel MgtE. The MgtE variants likely allow Mn(2+) entry via loss of a gating mechanism that normally holds the transporter in the closed state when cellular Mg(2+) levels are high. Both MgtE-dependent and MgtE-independent suppressor phenotypes were recapitulated by magnesium-limited growth of the mntH strain. Growth studies of wild-type cells suggest that manganese is toxic to cells when environmental magnesium is low. Moreover, extracellular manganese and magnesium levels were manipulated to inhibit growth without substantially altering the intracellular content of either metal, implying that manganese toxicity depends on its cellular distribution rather than the absolute concentration. Mg(2+) -dependent enzyme activities were found to be inhibited or stimulated by Mn(2+) . We conclude that Mn(2+) can occupy Mg(2+) binding sites in cells, and suggest that Mg(2+) -dependent processes are targets of manganese toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.