ArticleUrology2014
Preclinical safety and effectiveness studies of ultrasonic propulsion of kidney stones.
Article in Urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- First In-Human Burst Wave Lithotripsy for Kidney Stone Comminution: Initial Two Case Studies.Journal of endourology · 2021Trial
- First in Human Clinical Trial of Ultrasonic Propulsion of Kidney Stones.The Journal of urology · 2016Trial
- Animal models for calcium oxalate kidney stone research.Zoological research · 2026Review
- Removal of Small, Asymptomatic Kidney Stones and Relapse. Reply.The New England journal of medicine · 2022Article
- Recent Advances in the Science of Burst Wave Lithotripsy and Ultrasonic Propulsion.BME frontiers · 2022Article
- Quantitative Assessment of Effectiveness of Ultrasonic Propulsion of Kidney Stones.Journal of endourology · 2019Article
- Innovations in Ultrasound Technology in the Management of Kidney Stones.The Urologic clinics of North America · 2019Review
- Update on clinical trials of kidney stone repositioning and preclinical results of stone breaking with one system.Proceedings of meetings on acoustics. Acoustical Society of America · 2018Article
- Combined Burst Wave Lithotripsy and Ultrasonic Propulsion for Improved Urinary Stone Fragmentation.Journal of endourology · 2018Article
- Article
- Characterizing the Acoustic Output of an Ultrasonic Propulsion Device for Urinary Stones.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Article
- Safety and Effectiveness of a Longer Focal Beam and Burst Duration in Ultrasonic Propulsion for Repositioning Urinary Stones and Fragments.Journal of endourology · 2017Article
- Evaluation of Renal Calculi Passage While Riding a Roller Coaster.The Journal of the American Osteopathic Association · 2017Article
- Shock formation and nonlinear saturation effects in the ultrasound field of a diagnostic curvilinear probe.The Journal of the Acoustical Society of America · 2017Article
- DEVELOPING COMPLETE ULTRASONIC MANAGEMENT OF KIDNEY STONES FOR SPACEFLIGHT.The journal of space safety engineering · 2016Article
- Urinary Stone Disease: Advancing Knowledge, Patient Care, and Population Health.Clinical journal of the American Society of Nephrology : CJASN · 2016Review
- Ultrasonic propulsion of kidney stones.Current opinion in urology · 2016Review
- Non-invasive measurement of the temperature rise in tissue surrounding a kidney stone subjected to ultrasonic propulsion.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2015Article
- Ultrasonic propulsion of kidney stones: preliminary results of human feasibility study.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2014Article
- Nonlinear Effects in Ultrasound Fields of Diagnostic-type Transducers Used for Kidney Stone Propulsion: Characterization in Water.AIP conference proceedingsArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo provide an update on a research device to ultrasonically reposition kidney stones transcutaneously. This article reports preclinical safety and effectiveness studies, survival data, modifications of the system, and testing in a stone-forming porcine model. These data formed the basis for regulatory approval to test the device in humans. MATERIALS AND
methodsThe ultrasound burst was shortened to 50 ms from previous investigations with 1-s bursts. Focused ultrasound was used to expel 2- to 5-mm calcium oxalate monohydrate stones placed ureteroscopically in 5 pigs. Additionally, de novo stones were imaged and repositioned in a stone-forming porcine model. Acute safety studies were performed targeting 2 kidneys (6 sites) and 3 pancreases (8 sites). Survival studies followed 10 animals for 1 week after simulated treatment. Serum and urine analyses were performed, and tissues were evaluated histologically.
resultsAll ureteroscopically implanted stones (6/6) were repositioned out of the kidney in 14 ± 8 minutes with 13 ± 6 bursts. On average, 3 bursts moved a stone more than 4 mm and collectively accounted for the majority of relocation. Stones (3 mm) were detected and repositioned in the 200-kg stone-forming model. No injury was detected in the acute or survival studies.
conclusionUltrasonic propulsion is safe and effective in the porcine model. Stones were expelled from the kidney. De novo stones formed in a large porcine model were repositioned. No adverse effects were identified with the acute studies directly targeting kidney or pancreatic tissue or during the survival studies indicating no evidence of delayed tissue injury.
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Registered trials
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