Evidence map›Paper›PMID 24974797›Full record

ArticleNature neuroscience2014

Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.

Jerel K Mueller, Erinn M Grigsby, Vincent Prevosto, Frank W Petraglia, Hrishikesh Rao, Zhi-De Deng, Angel V Peterchev, Marc A Sommer, Tobias Egner, Michael L Platt and 1 more

Registry-linked trialOpen access · greenAbstract readTechnical Report
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06633913 (Neural Effects of Transcranial Magnetic Stimulation Using Concurrent Functional Magnetic Resonance Imaging), which is not on this map. Cited by 79 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06633913 narecruitingnot on this mapstarted 2024, after this paper: background citation

Neural Effects of Transcranial Magnetic Stimulation Using Concurrent Functional Magnetic Resonance Imaging

TypeinterventionalSponsorJing JiangRan2024 to 2029Enrolled97ConditionsHealthy Control, DepressionArmsspTMS-TBS-spTMS
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 162 citations in OpenAlex.

  1. Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Pooled it
  2. Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021
    Guideline
  3. Pooled it
  4. Review
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  10. Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
    Review
  11. Article
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  20. Review

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jerel K MuellerDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Erinn M Grigsby1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA.
Vincent PrevostoDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Frank W PetragliaDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Hrishikesh RaoDepartment of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Zhi-De DengDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Angel V Peterchev1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA. [3] Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA. [4] Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, USA.
Marc A Sommer1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, USA. [3] Center for Cognitive Neuroscience, Duke University, Durham, North Carolina, USA. [4] Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, USA.
Tobias Egner1] Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, USA. [2] Center for Cognitive Neuroscience, Duke University, Durham, North Carolina, USA. [3] Department of Psychology &Neuroscience, Duke University, Durham, North Carolina, USA.ORCID 0000000179563241
Michael L Platt1] Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, USA. [2] Center for Cognitive Neuroscience, Duke University, Durham, North Carolina, USA. [3] Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, USA.
Warren M Grill1] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [2] Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina, USA. [3] Duke Institute for Brain Sciences, Duke University, Durham, North Carolina, USA. [4] Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina, USA. [5] Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Duke University · US

Funding

Effects of Transcranial Magnetic Stimulation on Neurons in Behaving PrimatesR21NS078687 · NINDS · DUKE UNIVERSITY · PI SOMMER, MARC A · 2012 to 2013
$403k
NINDS NIH HHS R21 NS078687
6 · The paper itself

Abstract

Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ∼1 ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared with sham stimulation. This methodology is compatible with standard equipment in primate laboratories, allowing easy implementation. Application of these tools will facilitate the refinement of next generation TMS devices, experiments and treatment protocols.

Indexed as

Action PotentialsAnimalsArtifactsElectrodesEquipment DesignFemaleMacaca mulattaMaleNeuronsPatch-Clamp TechniquesPrefrontal CortexTranscranial Magnetic Stimulation

Identifiers

PMID24974797
PMCPMC4115015
OpenAlexW2146803302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.