ReviewExperimental animals2014
Mechanism of fertilization: a modern view.
Review in Experimental animals, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- The Sperm Acrosomal Reaction Depends on the Function of Both Na,K-ATPase α1 and α4 Isoforms.International journal of molecular sciences · 2026Article
- Micro-rubbing sperm immobilization promotes fertilization and oocyte utilization in intracytoplasmic sperm injection.Journal of ovarian research · 2025Article
- Optical coherence tomography for dynamic investigation of mammalian reproductive processes.Molecular reproduction and development · 2023Review
- The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding.Molecular biomedicine · 2022Article
- Mechanisms of Sperm-Egg Interactions: What Ascidian Fertilization Research Has Taught Us.Cells · 2022Review
- Testis-enrichedTranslational andrology and urology · 2022Article
- Role of Integrins in Sperm Activation and Fertilization.International journal of molecular sciences · 2021Review
- Find and fuse: Unsolved mysteries in sperm-egg recognition.PLoS biology · 2020Review
- Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Epididymal proteins Binder of SPerm Homologs 1 and 2 (BSPH1/2) are dispensable for male fertility and sperm motility in mice.Scientific reports · 2020Article
- Post-ejaculatory modifications to sperm (PEMS).Biological reviews of the Cambridge Philosophical Society · 2020Review
- GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse.BMC biology · 2019Article
- The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice.Scientific reports · 2018Article
- Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9.Reproductive medicine and biology · 2018Review
- Exposure to high ambient temperatures alters embryology in rabbits.International journal of biometeorology · 2017Article
- Roles of the reproductive tract in modifications of the sperm membrane surface.The Journal of reproduction and development · 2016Review
- Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Gamete activation: basic knowledge and clinical applications.Human reproduction update · 2016Review
- Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models.Asian journal of andrologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite numerous studies on mammalian fertilization, the mechanisms of fertilization-including the timing of acrosome reaction-remain largely unknown; more accurately described, the classical theory built upon years of layered experimental data is being challenged by recent conflicting evidence provided by gene-manipulated animals. Although in vitro fertilization remains our central research tool, the classical theory's decline reminds us of the importance of in vivo observations. Here, I describe the essential roles of gene-manipulated animals in elucidating the mechanism of fertilization and the pitfalls of in vitro fertilization studies trapping many researchers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.