ReviewNeuromolecular medicine2014
Diabetes mellitus and disturbances in brain connectivity: a bidirectional relationship?
Review in Neuromolecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder and Bipolar Depression: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials.Journal of clinical medicine · 2024Article
- Abnormal resting-state functional connectivity of hippocampal subregions in type 2 diabetes mellitus-associated cognitive decline.Frontiers in psychiatry · 2024Article
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- Article
- The clinical characterization of the adult patient with depression aimed at personalization of management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions.Canadian journal of physiology and pharmacology · 2020Article
- Impact of Diabetes on the Symptoms of Breast Cancer Survivors.Oncology nursing forum · 2019Article
- NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia.Pharmacological research · 2019Article
- Poststroke cognitive impairment and hippocampal neurovascular remodeling: the impact of diabetes and sex.American journal of physiology. Heart and circulatory physiology · 2018Article
- Recognition and Treatment of Cognitive Dysfunction in Major Depressive Disorder.Frontiers in psychiatry · 2018Review
- Diabetic aggravation of stroke and animal models.Experimental neurology · 2017Review
- Deconstructing Diabetes and Depression: Clinical Context, Treatment Strategies, and New Directions.Focus (American Psychiatric Publishing) · 2016Article
- Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients.Frontiers in neuroscience · 2016Article
- Short and long term neuro-behavioral alterations in type 1 diabetes mellitus pediatric population.World journal of diabetes · 2015Review
- Beyond Monoamines-Novel Targets for Treatment-Resistant Depression: A Comprehensive Review.Current neuropharmacology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) is associated with deficits across multiple cognitive domains. The observed impairments in cognitive function are hypothesized to be subserved by alterations in brain structure and function. Several lines of evidence indicate that alterations in glial integrity and function, as well as abnormal synchrony within brain circuits and associated networks, are observed in adults with DM. Microangiopathy and alterations in insulin homeostasis appear to be principal effector systems, although a unitary explanation subsuming the complex etiopathology of white matter in DM is unavailable. A contemporary model of disease pathophysiology for several mental disorders, including but not limited to mood disorders, posits abnormalities in the synchronization of cellular systems in circuits. The observation that similar abnormalities occur in diabetic populations provides the basis for hypothesizing the convergence of pathoetiological factors. Herein, we propose that abnormal structure, function and chemical composition as well as synchrony within and between circuits is an accompaniment of DM and is shared in common with several mental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.