Evidence map›Paper›PMID 24974157›Full record

ReviewTrends in immunology2014

The spatiotemporal cellular dynamics of lung immunity.

Efrat Lelkes, Mark B Headley, Emily E Thornton, Mark R Looney, Matthew F Krummel

Abstract readReview
In one paragraph

Review in Trends in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Downregulation of calponin 2 contributes to the quiescence of lung macrophages.American journal of physiology. Cell physiology · 2019
    Article
  10. Article
  11. Article
  12. Cortical Actin Dynamics in Endothelial Permeability.Current topics in membranes · 2018
    Article
  13. Article
  14. Article
  15. Article
  16. Ex vivo Live Imaging of Lung Metastasis and Their Microenvironment.Journal of visualized experiments : JoVE · 2016
    Article
  17. Article
  18. Intravital
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Efrat LelkesDepartment of Pediatrics, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA; Department of Pathology, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA.
Mark B HeadleyDepartment of Pathology, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA.
Emily E ThorntonDepartment of Pathology, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA.
Mark R LooneyDepartment of Medicine, University of California-San Francisco, 513 Parnassus Avenue, HSE 1355A, San Francisco, CA 94143-0511, USA.
Matthew F KrummelDepartment of Pathology, University of California-San Francisco, 513 Parnassus Avenue, HSW 518, San Francisco, CA 94143-0511, USA. Electronic address: Matthew.Krummel@ucsf.edu.

Funding

Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1M
Tools for Analysis of Airway InflammationP01HL024136 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCDONALD, DONALD M · 1985 to 2014
$23.3M
MOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0M
Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
Platelet and megakaryocyte biology in the normal and injured lungR01HL107386 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOONEY, MARK ROBERTS · 2011 to 2020
$4.2M
Epithelial Progenitor Cells in Lung Repair and RegenerationU01HL111054 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAPMAN, HAROLD A, CHUANG, PAO-TIEN · 2012 to 2016
$3.2M
Child Health Career Development Program at UCSFK12HD072222 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 2013 to 2017
$2.0M
Defining the First Hours of Lung metastasis using Intravital Live-ImagingR21CA167601 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2012 to 2013
$324k
NCI NIH HHS R21 CA167601NCI NIH HHS T32 CA108462NHLBI NIH HHS P01 HL024136NHLBI NIH HHS R01 HL107386NHLBI NIH HHS U01 HL111054NIAID NIH HHS T32 AI007334NIAID NIH HHS U19 AI077439NICHD NIH HHS K12 HD000850NICHD NIH HHS K12 HD072222
6 · The paper itself

Abstract

The lung is a complex structure that is interdigitated with immune cells. Understanding the 4D process of normal and defective lung function and immunity has been a centuries-old problem. Challenges intrinsic to the lung have limited adequate microscopic evaluation of its cellular dynamics in real time, until recently. Because of emerging technologies, we now recognize alveolar-to-airway transport of inhaled antigen. We understand the nature of neutrophil entry during lung injury and are learning more about cellular interactions during inflammatory states. Insights are also accumulating in lung development and the metastatic niche of the lung. Here we assess the developing technology of lung imaging, its merits for studies of pathophysiology and areas where further advances are needed.

Indexed as

AnimalsCell CommunicationHumansImaging, Three-DimensionalInflammationLungLung NeoplasmsOrganogenesis

Identifiers

PMID24974157
PMCPMC4124173

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.