ArticleNeuroradiology2014
Applicability of apparent diffusion coefficient ratios in preoperative diagnosis of common pediatric cerebellar tumors across two institutions.
Article in Neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Plasma lipidomics profiling to identify signatures of pediatric medulloblastoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Diagnostic value of MRI and diffusion-weighted imaging in dysthyroid optic neuropathy: a cross-sectional study providing insights into predictive parameters and pathogenesis.Neuroradiology · 2025Article
- Diagnostic Utility of Diffusion-Weighted Imaging in Distinguishing Common Pediatric Posterior Fossa Tumors: A Single Center Retrospective Study.Turkish archives of pediatrics · 2024Article
- [Pediatric posterior fossa tumors].Radiologie (Heidelberg, Germany) · 2023Review
- Cerebellar pilocytic astrocytoma. Retrospective cohort study assessing postoperative functional outcome, cerebellar mutism and hydrocephalus.World neurosurgery: X · 2023Article
- Diffusion Weighted Imaging in Neuro-Oncology: Diagnosis, Post-Treatment Changes, and Advanced Sequences-An Updated Review.Cancers · 2023Review
- The Diagnostic Efficiency of Quantitative Diffusion Weighted Imaging in Differentiating Medulloblastoma from Posterior Fossa Tumors: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- MR Imaging of Pediatric Brain Tumors.Diagnostics (Basel, Switzerland) · 2022Review
- Automatic Machine Learning to Differentiate Pediatric Posterior Fossa Tumors on Routine MR Imaging.AJNR. American journal of neuroradiology · 2020Article
- Septal dysembryoplastic neuroepithelial tumor: a comprehensive clinical, imaging, histopathologic, and molecular analysis.Neuro-oncology · 2019Article
- Can apparent diffusion coefficient values help distinguish between different types of pediatric brain tumors?European journal of radiology open · 2019Article
- Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis.Acta neuropathologica communications · 2018Article
- Response assessment in medulloblastoma and leptomeningeal seeding tumors: recommendations from the Response Assessment in Pediatric Neuro-Oncology committee.Neuro-oncology · 2018Review
- Apparent diffusion coefficient in differentiation of pediatric posterior fossa tumors.Japanese journal of radiology · 2017Article
- Cerebellopontine angle tumors in young children, displaying cranial nerve deficits, and restricted diffusion on diffusion-weighted imaging: a new clinical triad for atypical teratoid/rhabdoid tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Relative ADC and Location Differ between Posterior Fossa Pilocytic Astrocytomas with and without Gangliocytic Differentiation.AJNR. American journal of neuroradiology · 2016Article
- Apparent diffusion coefficient mapping in medulloblastoma predicts non-infiltrative surgical planes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Pediatric cerebellar astrocytoma: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe purpose of our study was to test the accuracy and applicability of decision rules utilizing apparent diffusion coefficient (ADC) ratios on accurate preoperative diagnosis of common pediatric cerebellar tumors across two institutions.
methodsIn this HIPAA-compliant, IRB-approved study, performed at two institutions, 140 pediatric cerebellar tumors were included. Two separate reviewers placed regions of interest on the solid components of 140 tumors (98 at site A and 42 at site B) and normal brain on the ADC maps. The third reviewer who was blinded to the histopathological diagnoses made the same measurements on 140 patients to validate the data. Tumor to normal brain ADC ratios were calculated. Receiver operator curve (ROC) analysis was performed to generate thresholds to discriminate tumors. Utility of decision rules based on these thresholds was tested.
resultsWhile ADC values of medulloblastomas were different between the sites, there was no difference among the ADC ratios of medulloblastomas, pilocytic astrocytomas, ependymomas, and atypical teratoid rhabdoid tumors between the sites. ADC ratio of ≥1.8 correctly discriminated pilocytic astrocytomas from ependymomas with a sensitivity of 0.83 and a specificity of 0.78. ADC ratio of <1.2 correctly discriminated ependymomas from embryonal tumors with a sensitivity of 0.87 and a specificity of 0.83. The proposed decision rules correctly discriminated 120 of the 140 tumors (85.71%). Age ≥2 years criterion correctly sorted medulloblastomas in 84.48% of patients and age <2 years correctly distinguished atypical teratoid rhabdoid tumors in 90.00% of patients with embryonal tumors.
conclusionsDecision rules based on ADC ratios are applicable across two institutions in the accurate preoperative diagnosis of common pediatric cerebellar tumors.
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