Evidence map›Paper›PMID 24974008›Full record

ArticleBiomaterials2014

The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation.

Archana V Boopathy, Pao Lin Che, Inthirai Somasuntharam, Vincent F Fiore, E Bernadette Cabigas, Kiwon Ban, Milton E Brown, Yoshie Narui, Thomas H Barker, Young-Sup Yoon and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Self-assembling peptide scaffolds in the clinic.NPJ Regenerative medicine · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Peptide-Based Functional Biomaterials for Soft-Tissue Repair.Frontiers in bioengineering and biotechnology · 2019
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. [Self-assembling peptide GFS-4 nanofiber scaffolds for three-dimensional cell cultures and myocardial infarction repair].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Archana V BoopathyWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Interdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Pao Lin CheWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA.
Inthirai SomasuntharamWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Interdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Vincent F FioreWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
E Bernadette CabigasWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA.
Kiwon BanDivision of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Milton E BrownWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Yoshie NaruiDepartment of Chemistry, Emory University, Atlanta, GA 30322, USA.
Thomas H BarkerWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Young-Sup YoonDivision of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Khalid SalaitaDepartment of Chemistry, Emory University, Atlanta, GA 30322, USA.
Andrés J GarcíaInterdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Michael E DavisWallace H. Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA; Interdisciplinary BioEngineering Program, Georgia Institute of Technology, Atlanta, GA 30332, USA; Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA; Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA; Emory+Children's Center for Cardiovascular Biology, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA. Electronic address: michael.davis@bme.emory.edu.
Emory University · USGeorgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

Cell therapy for diabetic peripheral neurovascular complicationsDP3DK094346 · NIDDK · EMORY UNIVERSITY · PI CHENG, XIAODONG, YOON, YOUNG-SUP · 2011 to 2011
$6.1M
Elucidating the Biophysical Mechanisms of Notch ActivationR01GM097399 · NIGMS · EMORY UNIVERSITY · PI SALAITA, KHALID S. · 2012 to 2016
$1.6M
NHLBI NIH HHS HHSN268201000043CNIDDK NIH HHS DP3 DK094346NIDDK NIH HHS DP3DK094346NIGMS NIH HHS R01 GM097399NIGMS NIH HHS R01-GM097399.
6 · The paper itself

Abstract

Myocardial infarction is the leading cause of death worldwide and phase I clinical trials utilizing cardiac progenitor cells (CPCs) have shown promising outcomes. Notch1 signaling plays a critical role in cardiac development and in the survival, cardiogenic lineage commitment, and differentiation of cardiac stem/progenitor cells. In this study, we functionalized self-assembling peptide (SAP) hydrogels with a peptide mimic of the Notch1 ligand Jagged1 (RJ) to evaluate the therapeutic benefit of CPC delivery in the hydrogels in a rat model of myocardial infarction. The behavior of CPCs cultured in the 3D hydrogels in vitro including gene expression, proliferation, and growth factor production was evaluated. Interestingly, we observed Notch1 activation to be dependent on hydrogel polymer density/stiffness with synergistic increase in presence of RJ. Our results show that RJ mediated Notch1 activation depending on hydrogel concentration differentially regulated cardiogenic gene expression, proliferation, and growth factor production in CPCs in vitro. In rats subjected to experimental myocardial infarction, improvement in acute retention and cardiac function was observed following cell therapy in RJ hydrogels compared to unmodified or scrambled peptide containing hydrogels. This study demonstrates the potential therapeutic benefit of functionalizing SAP hydrogels with RJ for CPC based cardiac repair.

Indexed as

AnimalsBiocompatible MaterialsCell DifferentiationCell MovementCHO CellsColoring AgentsCricetinaeCricetulusFemaleFlow CytometryGene Expression ProfilingGene Expression RegulationHydrogelsMiceMyocardial InfarctionMyocardiumBiocompatible MaterialsColoring AgentsHydrogelsNotch1 protein, mouseNotch1 protein, ratPeptidesPolymersReceptor, Notch1Gene expressionHeartHydrogelProgenitor cellSelf assembling peptide

Identifiers

PMID24974008
PMCPMC4150689
OpenAlexW2167605950

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.