ArticleIndian heart journal
Relook at lipoprotein (A): independent risk factor of coronary artery disease in north Indian population.
Article in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Elevated Lipoprotein(a) in Asian Populations and its Implications for Cardiovascular Disease.JACC. Asia · 2026Review
- Lipoprotein(a) and premature myocardial infarction: Mechanistic insights and implications for PCI-era residual risk.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- Role of Lipoprotein(a) in Atherosclerotic Cardiovascular Disease in South Asian Individuals.Journal of the American Heart Association · 2025Review
- Association of lipoprotein (a) with coronary artery disease in a South Asian population: A case-control study.PloS one · 2022Observational
- Lipoprotein(a) and lipid profiles of patients awaiting coronary artery bypass graft; a cross sectional study.BMC cardiovascular disorders · 2016Article
- Vascular Disease in Young Indians (20-40 years): Role of Ischemic Heart Disease.Journal of clinical and diagnostic research : JCDR · 2016Review
- Conventional and Advanced Lipid Parameters in Premature Coronary Artery Disease Patients in India.Journal of clinical and diagnostic research : JCDR · 2015Article
- Lipoprotein(a): An underrecognized genetic risk factor for malignant coronary artery disease in young Indians.Indian heart journalReview
- Correlation of lipoprotein (a) levels and plaque morphology in very young acute coronary syndrome patients using optical coherence tomography.Indian heart journalObservational
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7 authors.
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Abstract
aimsLipoprotein (a) [Lp(a)] levels have shown wide ethnic variations. Sparse data on mean Lp(a) levels, its link with clinical variables and severity of coronary artery disease (CAD) in North Indian population needed further studies.
methods150 patients, each of single vessel disease (SVD), double vessel disease (DVD) and triple vessel disease (TVD) with 150 healthy controls were drawn for the study. Serum Lp(a) estimation was performed by immunoturbidimetric method.
resultsLp(a) had a skewed distribution. Median Lp(a) level was significantly raised in cases as compared to controls (median 30.30 vs. 20 mg/dl, p < 0.001). Cases with acute coronary syndrome (ACS, 55.8%) had significantly higher median Lp(a) levels as compared to those with chronic stable angina (35.4 mg/dl vs. 23 mg/dl, p < 0.001). Significant difference in median Lp(a) levels were observed in patients with DVD or TVD versus control (30, 39.05 vs 20 mg/dl, p < 0.008). Lp(a) level was found to be an independent risk factor for CAD (AOR{adjusted odds ratio} 1.018, 95% CI 1.010-1.027; p < 0.001). Analysis using Lp(a) as categorical variable showed that progressive increase in Lp(a) concentration was associated with increased risk of CAD [AOR from lowest to highest quartile (1, 1.04, 1.43 and 2.65, p value for trend = 0.00026)]. Multivariably AOR of CAD for subjects with Lp(a) in the highest quartile (above 40 mg/dl) compared to those with Lp(a) ≤40 mg/dl was 2.308 (95% CI 1.465-3.636, p < 0.001).
conclusionLp(a) above 40 mg/dl (corresponding to 75th percentile)assessed by an isoform insensitive assay is an independent risk factor for CAD. Raised Lp(a) level is also associated with increased risk of ACS and multivessel CAD.
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