ArticleBiochimica et biophysica acta2014
Sphingolipids and mitochondrial function in budding yeast.
Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Sphingolipid metabolism drives mitochondria remodeling during aging and oxidative stress.bioRxiv : the preprint server for biology · 2025Article
- Reign in the membrane: How common lipids govern mitochondrial function.Current opinion in cell biology · 2020Review
- Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder.American journal of human genetics · 2018Article
- Stress-Activated Degradation of Sphingolipids Regulates Mitochondrial Function and Cell Death in Yeast.Oxidative medicine and cellular longevity · 2017Article
- The transcription factorsMicrobial cell (Graz, Austria) · 2016Article
- The Aspergillus fumigatus SchAMolecular microbiology · 2016Article
- Role of Inositol Phosphosphingolipid Phospholipase C1, the Yeast Homolog of Neutral Sphingomyelinases in DNA Damage Response and Diseases.Journal of lipids · 2015Review
- Angiotensin II type 1 receptor blockers increase tolerance of cells to copper and cisplatin.Microbial cell (Graz, Austria) · 2014Article
- The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.Molecules (Basel, Switzerland) · 2014Article
- Sphingolipids and mitochondrial function, lessons learned from yeast.Microbial cell (Graz, Austria) · 2014Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSphingolipids (SLs) are not only key components of cellular membranes, but also play an important role as signaling molecules in orchestrating both cell growth and apoptosis. In Saccharomyces cerevisiae, three complex SLs are present and hydrolysis of either of these species is catalyzed by the inositol phosphosphingolipid phospholipase C (Isc1p). Strikingly, mutants deficient in Isc1p display several hallmarks of mitochondrial dysfunction such as the inability to grow on a non-fermentative carbon course, increased oxidative stress and aberrant mitochondrial morphology. SCOPE OF REVIEW: In this review, we focus on the pivotal role of Isc1p in regulating mitochondrial function via SL metabolism, and on Sch9p as a central signal transducer. Sch9p is one of the main effectors of the target of rapamycin complex 1 (TORC1), which is regarded as a crucial signaling axis for the regulation of Isc1p-mediated events. Finally, we describe the retrograde response, a signaling event originating from mitochondria to the nucleus, which results in the induction of nuclear target genes. Intriguingly, the retrograde response also interacts with SL homeostasis. MAJOR
conclusionsAll of the above suggests a pivotal signaling role for SLs in maintaining correct mitochondrial function in budding yeast. GENERAL SIGNIFICANCE: Studies with budding yeast provide insight on SL signaling events that affect mitochondrial function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.