ReviewThe Journal of physiology2014
Synaptic mechanisms underlying cholinergic control of thalamic reticular nucleus neurons.
Review in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Electrical Coupling within Thalamocortical Networks Cumulatively Reduces Cortical Correlation to Sensory Inputs.eNeuro · 2026Article
- Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference?Journal of psychopharmacology (Oxford, England) · 2025Review
- Emerging Role of Tripartite Synaptic Transmission in the Pathomechanism of Autosomal-Dominant Sleep-Related Hypermotor Epilepsy.International journal of molecular sciences · 2025Review
- Subcortical Circuits Among Pedunculopontine Nucleus, Thalamus and Basal Ganglia Play Important Roles in Paroxysmal Arousal in Genetic Rat Models of Autosomal Dominant Sleep-Related Hypermotor Epilepsy.International journal of molecular sciences · 2025Article
- Navigation in brain networks is possible using only local measures.Scientific reports · 2025Article
- Article
- New perspectives on the basal forebrain cholinergic system in Alzheimer's disease.Neuroscience and biobehavioral reviews · 2023Review
- Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.Cell reports · 2023Article
- The relationship between cholinergic system brain structure and function in healthy adults and patients with mild cognitive impairment.Scientific reports · 2021Article
- Rapid multi-directed cholinergic transmission in the central nervous system.Nature communications · 2021Article
- Analysis of the Neuron Dynamics in Thalamic Reticular Nucleus by a Reduced Model.Frontiers in computational neuroscience · 2021Article
- Long-Term Value Memory in the Primate Posterior Thalamus for Fast Automatic Action.Current biology : CB · 2020Article
- Pathogenesis and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor.British journal of pharmacology · 2020Article
- Oscillating circuitries in the sleeping brain.Nature reviews. Neuroscience · 2019Review
- Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice.Molecular neurobiology · 2019Article
- Memantine protects thalamocortical hyper-glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc<sup/>.Pharmacology research & perspectives · 2019Article
- Effects of Cholinergic Neuromodulation on Thalamocortical Rhythms During NREM Sleep: A Model Study.Frontiers in computational neuroscience · 2019Article
- Article
- Cholinergic excitation complements glutamate in coding visual information in retinal ganglion cells.The Journal of physiology · 2018Article
- Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Neuronal networks of the thalamus are the target of extensive cholinergic projections from the basal forebrain and the brainstem. Activation of these afferents can regulate neuronal excitability, transmitter release, and firing patterns in thalamic networks, thereby altering the flow of sensory information during distinct behavioural states. However, cholinergic regulation in the thalamus has been primarily examined by using receptor agonist and antagonist, which has precluded a detailed understanding of the spatiotemporal dynamics that govern cholinergic signalling under physiological conditions. This review summarizes recent studies on cholinergic synaptic transmission in the thalamic reticular nucleus (TRN), a brain structure intimately involved in the control of sensory processing and the generation of rhythmic activity in the thalamocortical system. This work has shown that acetylcholine (ACh) released from individual axons can rapidly and reliably activate both pre- and postsynaptic cholinergic receptors, thereby controlling TRN neuronal activity with high spatiotemporal precision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.