ArticleBiomaterials2014
The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Antimicrobial coated intracortical probes reduce invading microbe abundance and subsequent neuroinflammation.Biomaterials · 2026Article
- Lipid nanoparticle-mediated Cd14 siRNA delivery ameliorates the acute inflammatory response to intracortical microelectrode implantation.Acta biomaterialia · 2026Article
- Dexamethasone-loaded platelet-inspired nanoparticles improve intracortical microelectrode recording performance.Nature communications · 2025Article
- Revolutionizing brain‒computer interfaces: overcoming biocompatibility challenges in implantable neural interfaces.Journal of nanobiotechnology · 2025Review
- Systemically administered platelet-inspired nanoparticles to reduce inflammation surrounding intracortical microelectrodes.Biomaterials · 2025Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- Bacteria invade the brain following intracortical microelectrode implantation, inducing gut-brain axis disruption and contributing to reduced microelectrode performance.Nature communications · 2025Article
- Long-Term Neural Recording Performance of PEDOT/CNT/Dexamethasone Coated Electrode Array Implanted in Visual Cortex of Rats.Advanced nanobiomed research · 2025Article
- Article
- Longitudinal changes in electrophysiology and widefield calcium imaging following electrode implantation.Journal of neural engineering · 2024Article
- Enhancing biocompatibility of the brain-machine interface: A review.Bioactive materials · 2024Review
- Comprehensive proteomic analysis of the differential expression of 62 proteins following intracortical microelectrode implantation.Scientific reports · 2024Article
- Corrigendum to "Platelets and Hemostatic Proteins are Co-Localized with Chronic Neuroinflammation Surrounding Implanted Intracortical Microelectrodes" [Acta Biomaterialia. Volume 166, August 2023, Pages 278-290].Acta biomaterialia · 2024Article
- Bacteria Invade the Brain Following Sterile Intracortical Microelectrode Implantation.Research square · 2024Article
- In Vivo Characterization of Intracortical Probes with Focused Ion Beam-Etched Nanopatterned Topographies.Micromachines · 2024Article
- Advanced age is not a barrier to chronic intracortical single-unit recording in rat cortex.Frontiers in neuroscience · 2024Article
- Flexible multifunctional titania nanotube array platform for biological interfacing.MRS bulletin · 2024Article
- The effect of a Mn(III)tetrakis(4-benzoic acid)porphyrin (MnTBAP) coating on the chronic recording performance of planar silicon intracortical microelectrode arrays.Biomaterials · 2023Article
- In Vivo Validation of a Mechanically Adaptive Microfluidic Intracortical Device as a Platform for Sustained Local Drug Delivery.Frontiers in biomaterials science · 2023Article
- Antioxidant Dimethyl Fumarate Temporarily but Not Chronically Improves Intracortical Microelectrode Performance.Micromachines · 2023Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Resident microglia and blood-borne macrophages have both been implicated to play a dominant role in mediating the neuroinflammatory response affecting implanted intracortical microelectrodes. However, the distinction between each cell type has not been demonstrated due to a lack of discriminating cellular markers. Understanding the subtle differences of each cell population in mediating neuroinflammation can aid in determining the appropriate therapeutic approaches to improve microelectrode performance. Therefore, the goal of this study is to characterize the role of infiltrating blood-derived cells, specifically macrophages, in mediating neuroinflammation following intracortical microelectrode implantation. Interestingly, we found no correlation between microglia and neuron populations at the microelectrode-tissue interface. On the other hand, blood-borne macrophages consistently dominated the infiltrating cell population following microelectrode implantation. Most importantly, we found a correlation between increased populations of blood-derived cells (including the total macrophage population) and neuron loss at the microelectrode-tissue interface. Specifically, the total macrophage population was greatest at two and sixteen weeks post implantation, at the same time points when we observed the lowest densities of neuronal survival in closest proximity to the implant. Together, our results suggest a dominant role of infiltrating macrophages, and not resident microglia, in mediating neurodegeneration following microelectrode implantation.
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