ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Frailty in the Honolulu-Asia Aging Study: deficit accumulation in a male cohort followed to 90% mortality.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Relative impact of multidomain lifestyle interventions on deficit accumulation frailty over 24 months in the U.S. POINTER trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Efficacy and Safety of Dapagliflozin According to Frailty in Patients With Heart Failure: A Prespecified Analysis of the DELIVER Trial.Circulation · 2022Trial
- Validation of a Deficit-Accumulation Frailty Index in the ASPirin in Reducing Events in the Elderly Study and Its Predictive Capacity for Disability-Free Survival.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Frailty Change and Major Osteoporotic Fracture in the Elderly: Data from the Global Longitudinal Study of Osteoporosis in Women 3-Year Hamilton Cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
- Frailty Index Progression Around Hypertension Diagnosis in 14 Countries.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Early-Life War Exposure and Later-Life Frailty Among Older Adults in Vietnam: Does War Hasten Aging?The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- A 6-year prospective clinical cohort study on the bidirectional association between frailty and depressive disorder.International journal of geriatric psychiatry · 2021Article
- Generating synthetic aging trajectories with a weighted network model using cross-sectional data.Scientific reports · 2020Article
- Drivers of Frailty from Adulthood into Old Age: Results from a 27-Year Longitudinal Population-Based Study in Sweden.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Frailty effects on non-demented cognitive trajectories are moderated by sex and Alzheimer's genetic risk.Alzheimer's research & therapy · 2019Article
- Frailty, transition in frailty status and all-cause mortality in older adults of a Taichung community-based population.BMC geriatrics · 2019Article
- The accumulation of deficits approach to describe frailty.PloS one · 2019Article
- Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people.Clinical interventions in aging · 2019Article
- Is frailty a stable predictor of mortality across time? Evidence from the Cognitive Function and Ageing Studies.Age and ageing · 2018Article
- Development of a Physiological Frailty Index for the World Trade Center General Responder Cohort.Current gerontology and geriatrics research · 2018Article
- Heterogeneity of Human Aging and Its Assessment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Cardiovascular Dysfunction and Frailty Among Older Adults in the Community: The ARIC Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Observational
- A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice.Scientific reports · 2017Article
- Climbing Stairs, Handrail Use, and Survival.The journal of nutrition, health & aging · 2017Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundA frailty index (FI) based on the accumulation of deficits typically has a submaximal limit at about 0.70. The objectives of this study were to examine how population characteristics of the FI change in the Honolulu-Asia Aging Study cohort, which has been followed to near-complete mortality. In particular, we were interested to see if the limit was exceeded.
methodsSecondary analysis of six waves of the Honolulu-Asia Aging Study. Men (n = 3,801) aged 71-93 years at baseline (1991) were followed until death (N = 3,455; 90.9%) or July 2012. FIs were calculated across six waves and the distribution at each wave was evaluated. Kaplan-Meier analyses and Cox proportional hazard models were performed to examine the relationship of frailty with mortality.
resultsAt each wave, frailty was nonlinearly associated with age, with acceleration in later years. The distributions of the FIs were skewed with long right tails. Despite the increasing mortality in each successive wave, the 99% submaximal limit never exceeded 0.65. The risk of death increased with increasing values of the FI (eg, the hazard rate increased by 1.44 [95% CI = 1.39-1.49] with each increment in the baseline FI grouping). Depending on the wave, the median survival of people with FI more than 0.5 ranged 0.84-2.04 years.
conclusionsEven in a study population followed to almost complete mortality, the limit to deficit accumulation did not exceed 0.65, confirming a quantifiable, maximum number of health deficits that older men can tolerate.
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