ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
Rapid emergence of daptomycin resistance in clinical isolates of Corynebacterium striatum… a cautionary tale.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Corynebacterium Striatum Native Valve Endocarditis.Pakistan journal of medical sciences · 2026Article
- Rapid acquisition of daptomycin resistance in aASM case reports · 2025Article
- Daptomycin forms a stable complex with phosphatidylglycerol for selective uptake to bacterial membrane.eLife · 2025Article
- Retrospective analysis of antimicrobial susceptibility profiles of non-Journal of clinical microbiology · 2024Article
- Emergence of Daptomycin Nonsusceptibility and Treatment Failure in Patients WithOpen forum infectious diseases · 2024Article
- Exploration of the role of the penicillin binding protein 2c (Pbp2c) in inducible β-lactam resistance inFrontiers in microbiology · 2024Article
- Article
- Clinical Profile of MonomicrobialOpen forum infectious diseases · 2022Article
- Article
- The challenge of antibiotic selection in prosthetic joint infections due to Corynebacterium striatum: a case report.BMC infectious diseases · 2022Article
- Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome ofInternational journal of molecular sciences · 2021Review
- Evaluating the Rapid Emergence of Daptomycin Resistance inJournal of clinical microbiology · 2021Article
- Infective Endocarditis Due toOpen forum infectious diseases · 2021Article
- From contamination to infective endocarditis-a population-based retrospective study of Corynebacterium isolated from blood cultures.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Bloodstream and catheter-related infections due to different clones of multidrug-resistant and biofilm producer Corynebacterium striatum.BMC infectious diseases · 2019Article
- Monomicrobial bone and joint infection due to Corynebacterium striatum: literature review and amoxicillin-rifampin combination as treatment perspective.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Mechanism of High-Level Daptomycin Resistance inmSphere · 2018Article
- Article
- Factors affecting the clinical relevance of Corynebacterium striatum isolated from blood cultures.PloS one · 2018Article
- When Good Bugs Go Bad: Epidemiology and Antimicrobial Resistance Profiles of Corynebacterium striatum, an Emerging Multidrug-Resistant, Opportunistic Pathogen.Antimicrobial agents and chemotherapy · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The objective of this study was to investigate the observation of daptomycin resistance in Corynebacterium striatum, both in vivo and in vitro. We describe a case of C. striatum bacteremia in a patient with a left ventricular assist device (LVAD); the initial isolate recovered was daptomycin susceptible with a minimum inhibitory concentration (MIC) of 0.125 μg/ml. Two months later, and after daptomycin therapy, the individual became bacteremic with an isolate of C. striatum with a daptomycin MIC of >256 μg/ml. To study the prevalence of daptomycin resistance in C. striatum, clinical isolates of C. striatum were grown in broth culture containing daptomycin to investigate the emergence of resistance to this antimicrobial. Molecular typing was used to evaluate serial isolates from the index patient and the clinical isolates of C. striatum we assayed. In vitro analysis of isolates from the index patient and 7 of 11 additional C. striatum isolates exhibited the emergence of high-level daptomycin resistance, despite initially demonstrating low MICs to this antimicrobial agent. This phenotype was persistent even after serial subculture in the absence of daptomycin. Together, these data demonstrate that caution should be taken when using daptomycin to treat high-inoculum infections and/or infections of indwelling medical devices with C. striatum. To our knowledge, this is the first report characterizing the emergence of daptomycin resistance in C. striatum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.