ArticleToxicological sciences : an official journal of the Society of Toxicology2014
Identification of Drosophila-based endpoints for the assessment and understanding of xenobiotic-mediated male reproductive adversities.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Reproductive Toxicity of Nanomaterials Using Silver Nanoparticles andMolecules (Basel, Switzerland) · 2024Article
- Female factors modulate Sex Peptide's association with sperm in Drosophila melanogaster.BMC biology · 2022Article
- Toxicity Assessment ofInternational journal of environmental research and public health · 2022Article
- Article
- Nosema ceranae, Fipronil and their combination compromise honey bee reproduction via changes in male physiology.Scientific reports · 2017Article
- Functional male accessory glands and fertility in Drosophila require novel ecdysone receptor.PLoS genetics · 2017Article
- Estrogen related receptor is required for the testicular development and for the normal sperm axoneme/mitochondrial derivatives in Drosophila males.Scientific reports · 2017Article
- Drone exposure to the systemic insecticide Fipronil indirectly impairs queen reproductive potential.Scientific reports · 2016Article
- Exposure to endosulfan influences sperm competition in Drosophila melanogaster.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Men are at risk of becoming completely infertile due to innumerable environmental chemicals and pollutants. These xenobiotics, hence, should be tested for their potential adverse effects on male fertility. However, the testing load, a monumental challenge for employing conventional animal models, compels the pursuit of alternative models. Towards this direction, we show here that Drosophila melanogaster, an invertebrate, with its well characterized/conserved male reproductive processes/proteome, recapitulates male reproductive toxicity phenotypes observed in mammals when exposed to a known reproductive toxicant, dibutyl phthalate (DBP). Analogous to mammals, exposure to DBP reduced fertility, sperm counts, seminal proteins, increased oxidative modification/damage in reproductive tract proteins and altered the activity of a hormone receptor (estrogen related receptor) in Drosophila males. In addition, we show here that DBP is metabolized to monobutyl phthalate (MBP) in exposed Drosophila males and that MBP is more toxic than DBP, as observed in higher organisms. These findings suggest Drosophila as a potential alternative to traditional animal models for the prescreening of chemicals for their reproductive adversities and also to gain mechanistic insights into chemical-mediated endocrine disruption and male infertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.