Evidence map›Paper›PMID 24972901›Full record

ArticleBMJ (Clinical research ed.)2014

Comparative safety of anesthetic type for hip fracture surgery in adults: retrospective cohort study.

Elisabetta Patorno, Mark D Neuman, Sebastian Schneeweiss, Helen Mogun, Brian T Bateman

3 registry-linked trialsOpen access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428257 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Hypobaric Rather Than Isobaric Bupivacaine to Prevent Anesthesia-induced Hypotension in Patients Undergoing Surgical Repair of Hip Fracture Under Continuous Spinal Anesthesia: a Prospective Randomized Controlled Study.

TypeinterventionalSponsorInstitut Kassab d'OrthopédieRan2015 to 2015Enrolled120ConditionsHip Fracture, HypotensionArmscontinuous spinal anesthesia, hypobaric bupivacaine, isobaric bupivacaine, ephedrine
NCT03116490 recruitingnot on this mapstarted 2026, after this paper: background citation

The Comparative Effects of Regional or General Anesthesia on the Prognosis of Hip Fracture Surgery on Elderly Patients

TypeobservationalSponsorWenzhou Medical UniversityRan2026 to 2028Enrolled600ConditionsPostoperative Complications, Postoperative MortalityArmsAnesthesia type
NCT04451538 naterminatednot on this mapstarted 2020, after this paper: background citation

Impact of Perioperative Nutritional Intervention on Perioperative Outcomes of Elderly Patients Having Hip Fracture Surgery: A Randomized Control Trial

TypeinterventionalSponsorPeking University First HospitalRan2020 to 2021Enrolled30ConditionsElderly Patients, Malnutrition, Hip Fractures, Nutritional InterventionArmsNutritional intervention group, Control group
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. La Tunisie medicale · 2023
    Trial
  7. Observational
  8. Racial and Ethnic Disparities in Regional Anesthesia: A Brief Review.Journal of racial and ethnic health disparities · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Comparative outcome of anaesthetic for elderly hip fracture.Journal of clinical orthopaedics and trauma · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Elisabetta PatornoDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA epatorno@partners.org.
Mark D NeumanDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sebastian SchneeweissDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.
Helen MogunDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA.
Brian T BatemanDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02120, USA Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Brigham and Women's Hospital · USHarvard University · USUniversity of Pennsylvania · US

Funding

Comparative safety & effectiveness of antihypertensive medications in pregnancyK08HD075831 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BATEMAN, BRIAN THOMAS · 2013 to 2017
$717k
Understanding Variations in Hip Fracture Outcomes across the Continuum of CareK08AG043548 · NIA · UNIVERSITY OF PENNSYLVANIA · PI NEUMAN, MARK DAVID · 2012 to 2016
$642k
NIA NIH HHS K08 AG043548NIA NIH HHS K08AG043548NICHD NIH HHS K08 HD075831NICHD NIH HHS K08HD075831
6 · The paper itself

Abstract

objectiveTo evaluate the effect of anesthesia type on the risk of in-hospital mortality among adults undergoing hip fracture surgery in the United States.

designRetrospective cohort study.

settingPremier research database, United States.

participants73,284 adults undergoing hip fracture surgery on hospital day 2 or greater between 2007 and 2011. Of those, 61,554 (84.0%) received general anesthesia, 6939 (9.5%) regional anesthesia, and 4791 (6.5%) combined general and regional anesthesia.

main outcome measureIn-hospital all cause mortality.

resultsIn-hospital deaths occurred in 1362 (2.2%) patients receiving general anesthesia, 144 (2.1%) receiving regional anesthesia, and 115 (2.4%) receiving combined anesthesia. In the multivariable adjusted analysis, when compared with general anesthesia the mortality risk did not differ significantly between regional anesthesia (risk ratio 0.93, 95% confidence interval 0.78 to 1.11) or combined anesthesia (1.00, 0.82 to 1.22). A mixed effects analysis accounting for differences between hospitals produced similar results: compared with general anesthesia the risk from regional anesthesia was 0.91 (0.75 to 1.10) and from combined anesthesia was 0.98 (0.79 to 1.21). Findings were also consistent in subgroup analyses.

conclusionsIn this large nationwide sample of hospital admissions, mortality risk did not differ significantly by anesthesia type among patients undergoing hip fracture surgery. Our results suggest that if the previously posited beneficial effect of regional anesthesia on short term mortality exists, it is likely to be more modest than previously reported.

Indexed as

Hospital MortalityAdolescentAdultAgedAged, 80 and overAnesthesia, ConductionAnesthesia, GeneralFemaleHip FracturesHospitals, RuralHospitals, TeachingHospitals, UrbanHumansMaleMiddle AgedRetrospective Studies

Identifiers

PMID24972901
PMCPMC4073666
OpenAlexW2130638130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.