ArticleBiology open2014
Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation.
Article in Biology open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Immune-mediated competition benefits protective microbes over pathogens in a novel host species.Heredity · 2022Article
- Therapeutic Effectiveness of Sinensetin Against Cancer and Other Human Complications: A Review of Biological Potential and Pharmacological Activities.Cardiovascular & hematological disorders drug targets · 2022Article
- Caenorhabditis elegans in high-throughput screens for anti-infective compounds.Current opinion in immunology · 2018Review
- Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin-resistant Staphylococcus aureus.Scientific reports · 2018Article
- Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162.Scientific reports · 2018Article
- Intrinsic JNK-MAPK pathway involvement requires daf-16-mediated immune response during Shigella flexneri infection in C. elegans.Immunologic research · 2017Article
- A Marine Actinomycete RescuesFrontiers in microbiology · 2017Article
- Raf-kinase inhibitor GW5074 shows antibacterial activity against methicillin-resistant Staphylococcus aureus and potentiates the activity of gentamicin.Future medicinal chemistry · 2016Article
- Beyond Traditional Antimicrobials: AFrontiers in microbiology · 2016Review
- Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile.Bioorganic & medicinal chemistry letters · 2015Article
- Curcumin rescues Caenorhabditis elegans from a Burkholderia pseudomallei infection.Frontiers in microbiology · 2015Article
- Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity.PloS one · 2014Article
- Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19.Frontiers in immunologyReview
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amidst growing concerns over the spread of antibiotic-resistant Staphylococcus aureus strains, the identification of alternative therapeutic molecules has become paramount. Previously, we utilized a Caenorhabditis elegans-S. aureus screening platform to identify potential anti-infective agents from a collection of natural extracts and synthetic compounds. One of the hits obtained from the screen was the aqueous extract of Orthosiphon stamineus leaves (UE-12) that enhanced the survival of infected nematodes without interfering with bacterial growth. In this study, we used a fluorescent transgenic reporter strain and observed that the repressed expression of the lys-7 defense gene in infected nematodes was restored in the presence of UE-12. Analysis of a selected panel of PMK-1 and DAF-16-regulated transcripts and loss-of-function mutants in these pathways indicates that the protective role of UE-12 is mediated via the p38 MAP kinase and insulin-like signaling pathways. Further analysis of a panel of known bioactive compounds of UE-12 proposed eupatorin (C18H16O7) as the possible candidate active molecule contributing to the anti-infective property of UE-12. Taken together, these findings strongly suggest that the O. stamineus leaf extract is a promising anti-infective agent that confers an advantage in survival against S. aureus infection by modulating the immune response of the infected host.
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