ArticleMolecular brain2014
Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem.
Article in Molecular brain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- System-level synchronization and subtype-specific modules govern brain-wide serotonin axon innervation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Serotonergic Control of Spine Morphology During Growth in Zebrafish.bioRxiv : the preprint server for biology · 2026Article
- An adult-stage transcriptional program for survival of serotonergic connectivity.Cell reports · 2022Article
- Article
- Lmx1b is required at multiple stages to build expansive serotonergic axon architectures.eLife · 2019Article
- The adaptive brain in mental health: overcoming inherited risk factors.Journal of psychiatry & neuroscience : JPN · 2017Article
- Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Outside the brain: an inside view on transgenic animal and stem cell-based models to examine neuronal serotonin-dependent regulation of HPA axis-controlled events during development and adult stages.Stem cell investigation · 2016Article
- Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency.Scientific reports · 2015Article
- Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin.PloS one · 2015Article
- Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling.Neuron · 2014Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundDespite the importance of 5-HT1A as a major target for the action of several anxiolytics/antidepressant drugs, little is known about its regulation in central serotonin (5-hydroxytryptamine, 5-HT) neurons.
resultsWe report that expression of 5-HT1A and the transcription factor Pet1 was impaired in the rostral raphe nuclei of mice lacking tryptophan hydroxylase 2 (Tph2) after birth. The downregulation of Pet1 was recapitulated in 5-Ht1a-/- mice. Using an explant culture system, we show that reduction of Pet1 and 5-HT1A was rescued in Tph2-/- brainstem by exogenous 5-HT. In contrast, 5-HT failed to rescue reduced expression of Pet1 in 5-Ht1a-/- brainstem explant culture.
conclusionsThese results suggest a causal relationship between 5-HT1A and Pet1, and reveal a potential mechanism by which 5-HT1A-Pet1 autoregulatory loop is maintained by 5-HT in a spatiotemporal-specific manner during postnatal development. Our results are relevant to understanding the pathophysiology of certain psychiatric and developmental disorders.
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