Evidence map›Paper›PMID 24971867›Full record

ArticleOsteoarthritis and cartilage2014

Association of hip and pelvic geometry with tibiofemoral osteoarthritis: multicenter osteoarthritis study (MOST).

A Boissonneault, J A Lynch, B L Wise, N A Segal, K D Gross, D W Murray, M C Nevitt, H G Pandit

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Osteoarthritis and cartilage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Article
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  8. Review
  9. Article
  10. Article
  11. The importance of hip shape in predicting hip osteoarthritis.Current treatment options in rheumatology · 2018
    Article
  12. Article
  13. Osteoarthritis year in review 2015: clinical.Osteoarthritis and cartilage · 2016
    Review
  14. State of the evidence.Current opinion in rheumatology · 2015
    Review
  15. Strong correlation between the morphology of the proximal femur and the geometry of the distal femoral trochlea.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2014
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

A BoissonneaultBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. Electronic address: aboissonneault@gmail.com.
J A LynchDepartment of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA.
B L WiseCenter for Musculoskeletal Health, University of California, Davis School of Medicine, Davis, CA, USA.
N A SegalDepartment of Orthopaedics and Rehabilitation, The University of Iowa, Carver College of Medicine, Iowa City, IA, USA.
K D GrossClinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA.
D W MurrayBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
M C NevittDepartment of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, USA.
H G PanditBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Nuffield Orthopaedic Centre · GBUniversity of California, San Francisco · USBoston University · USUniversity of California, Davis · USUniversity of Iowa · US

Funding

Multicenter Osteoarthritis Study (MOST) Second RenewalU01AG019069 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NEVITT, MICHAEL C · 2001 to 2020
$21.7M
WORK DISABILITY-- PERSONS WITH RHEUMATOID ARTHRITISP60AR047785 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2016
$18.0M
Multicenter Osteoarthritis Study (MOST) Second Renewal: Iowa Clinical CenterU01AG018832 · NIA · UNIVERSITY OF IOWA · PI SEGAL, NEIL A, TORNER, JAMES C · 2001 to 2020
$14.1M
Multicenter Osteoarthritis Study (MOST) Second Renewal - Boston UniversityU01AG018820 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2019
$13.6M
Multicenter Osteoarthritis Study (MOST) Second Renewal - UAB Clinical CenterU01AG018947 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 2001 to 2020
$13.2M
Building Interdisciplinary Research Careers in Womens Health at UC Davis - Administrative SupplementK12HD051958 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI LANE, NANCY E · 2005 to 2023
$9.6M
Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2015
$6.2M
Sex Differences in response to an exercise for hyperkyphosisP50AR063043 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LANE, NANCY E · 2012 to 2017
$5.7M
Unruptured Intracranial Aneurysms: Neurologic OutcomeR01NS048597 · NINDS · UNIVERSITY OF IOWA · PI TORNER, JAMES C · 2004 to 2007
$1.9M
NIAMS NIH HHS P50 AR060752NIAMS NIH HHS P50-AR060752NIAMS NIH HHS P50 AR063043NIAMS NIH HHS P50-AR063043NIAMS NIH HHS P60 AR047785NIA NIH HHS AG18820NIA NIH HHS AG18832NIA NIH HHS AG18947NIA NIH HHS AG19069NIA NIH HHS U01 AG018820NIA NIH HHS U01 AG018832NIA NIH HHS U01 AG018947NIA NIH HHS U01 AG019069NICHD NIH HHS K12 HD051958NINDS NIH HHS R01 NS048597
6 · The paper itself

Abstract

objectiveLateral tibiofemoral osteoarthritis (OA) is overall less common than medial tibiofemoral OA, but it is more prevalent in women. This may be explained by sex differences in hip and pelvic geometry. The aim of this study is to explore sex differences in hip and pelvic geometry and determine if such parameters are associated with the presence of compartment-specific knee OA.

methodsThis case-control study reports on 1,328 hips/knees from 664 participants and is an ancillary to the Multicenter Osteoarthritis Study (MOST). Of the 1,328 knees, 219 had lateral OA, 260 medial OA, and 849 no OA. Hip and pelvic measurements were taken from full-limb radiographs on the ipsilateral side of the knee of interest. After adjusting for covariates, means were compared between sexes and also between knees with medial and lateral OA vs no OA using separate regression models.

resultsWomen were shown to have a reduced femoral offset (FO) (mean 40.9 mm vs 45.9 mm; P = 0.001) and more valgus neck-shaft angle (mean 128.4° vs 125.9°; P < 0.001) compared to men. Compared to those with no OA, knees with lateral OA were associated with a reduced FO (P = 0.012), increased height of hip centre (HHC) (P = 0.003), more valgus neck-shaft angle (P = 0.042), and increased abductor angle (P = 0.031). Knees with medial OA were associated with a more varus neck-shaft angle (P = 0.043) and a decreased abductor angle (P = 0.003).

conclusionThese data suggest anatomical variations at the hip and pelvis are associated with compartment-specific knee OA and may help to explain sex differences in patterns of knee OA.

Indexed as

AgedBone MalalignmentCase-Control StudiesFemaleFemurHip JointHumansKnee JointMaleMiddle AgedOsteoarthritis, KneePelvic BonesRadiographySex CharacteristicsSex FactorsTibiaBiomechanicsHip geometryKnee alignmentKnee osteoarthritis

Identifiers

PMID24971867
PMCPMC4195737
OpenAlexW2144520518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.