Trial reportApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2014
The independent and combined effects of exercise training and reducing sedentary behavior on cardiometabolic risk factors.
Trial report in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06270810 (Cardiometabolic Effects of Increasing Non-Exercise Physical Activity Combined With Aerobic Exercise in Overweight Young Women), which is not on this map. Cited by 30 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiometabolic Effects of Increasing Non-Exercise Physical Activity Combined With Aerobic Exercise in Overweight Young Women
Who cites it
30 citing papers in PubMed, 7 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- The effect of exercise on cardiovascular disease risk factors in sedentary population: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Effect of exercise on cardiometabolic health of adults with overweight or obesity: Focus on blood pressure, insulin resistance, and intrahepatic fat-A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Effects of sedentary behaviour interventions on biomarkers of cardiometabolic risk in adults: systematic review with meta-analyses.British journal of sports medicine · 2021Pooled it
- Interventions outside the workplace for reducing sedentary behaviour in adults under 60 years of age.The Cochrane database of systematic reviews · 2020Pooled it
- The energy expenditure benefits of reallocating sedentary time with physical activity: a systematic review and meta-analysis.Journal of public health (Oxford, England) · 2018Pooled it
- Pooled it
- A comparison of the effectiveness of physical activity and sedentary behaviour interventions in reducing sedentary time in adults: a systematic review and meta-analysis of controlled trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2014Pooled it
- Effects of reduced sedentary time on resting, exercise and post-exercise blood pressure in inactive adults with metabolic syndrome - a six-month exploratory RCT.Journal of human hypertension · 2024Trial
- Targeting Sedentary Behavior in CKD: A Pilot and Feasibility Randomized Controlled Trial.Clinical journal of the American Society of Nephrology : CJASN · 2021Trial
- Trial
- An Evaluation of Accelerometer-derived Metrics to Assess Daily Behavioral Patterns.Medicine and science in sports and exercise · 2017Trial
- Effects of reducing sedentary behaviour on cardiovascular health, skeletal muscle oxidative capacity and functional exercise capacity in sedentary adults: a randomised controlled trial.BMJ open sport & exercise medicine · 2026Article
- Change in Free-Living Daily Steps does not Affect VOInternational journal of exercise science · 2025Article
- Considering the 24-Hour Activity Cycle in Older Adults.American journal of lifestyle medicine · 2025Review
- The effect of a structured running exercise intervention on non-exercise physical activity and sedentary behaviour in persons with mild Multiple Sclerosis and healthy controls.Journal of activity, sedentary and sleep behaviors · 2023Article
- Physiology of sedentary behavior.Physiological reviews · 2023Review
- Article
- The utility of the integrated behavior change model as an extension of the theory of planned behavior.Frontiers in psychology · 2022Article
- Effect of Reducing Sedentary Behavior on Blood Pressure (RESET BP): Rationale, design, and methods.Contemporary clinical trials · 2021Article
- Effects of Circuit Weight-Interval Training on Physical Fitness, Cardiac Autonomic Control, and Quality of Life in Sedentary Workers.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
This pilot study examined if the combination of exercise training and reducing sedentary time (ST) results in greater changes to health markers than either intervention alone. Fifty-seven overweight/obese participants (19 males/39 females) (mean ± SD; age, 43.6 ± 9.9 years; body mass index (BMI), 35.1 ± 4.6 kg·m(-2)) completed the 12-week study and were randomly assigned to (i) EX: exercise 5 days·week(-1) for 40 min·session(-1) at moderate intensity; (ii) rST: reduce ST and increase nonexercise physical activity; (iii) EX-rST: combination of EX and rST; and (iv) CON: maintain behavior. Fasting lipids, blood pressure (BP), peak oxygen uptake, BMI, and 2-h oral glucose tolerance tests were completed pre- and post-intervention. EX and EX-rST increased peak oxygen uptake by ∼10% and decreased systolic BP (both p < 0.001). BMI decreased by -3.3% (95% confidence interval: -4.6% to -1.9%) for EX-rST and -2.2% (-3.5% to 0.0%) for EX. EX-rST significantly increased composite insulin-sensitivity index by 17.8% (2.8% to 32.8%) and decreased insulin area under the curve by 19.4% (-31.4% to -7.3%). No other groups improved in insulin action variables. rST group decreased ST by 7% (∼50 min·day(-1)); however, BP was the only health-related outcome that improved. EX and EX-rST improved peak oxygen uptake and BMI, providing further evidence that moderate-intensity exercise is beneficial. The within-group analysis provides preliminary evidence that exercising and reducing ST may result in improvements in metabolic biomarkers that are not seen with exercise alone, though between-group differences did not reach statistical significance. Future studies, with larger samples, should examine health-related outcomes resulting from greater reductions in ST over longer intervention periods.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.