ArticleGut microbes
Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis.
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- The Role of Virulence Factors in Neonatal Sepsis Caused by Enterobacterales: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- A Non-genotoxic Variant of Escherichia coli Nissle 1917 EcN 2.0 Overexpressing Microcins Reduces Intestinal Carriage of ST131 ESBL-Producing Escherichia coli.Probiotics and antimicrobial proteins · 2026Article
- Early-onset cancers: Biological bases and clinical implications.Cell reports. Medicine · 2024Review
- Preclinical and clinical evidence of the association of colibactin-producingWorld journal of gastroenterology · 2024Article
- Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients.BMC cancer · 2024Article
- The synthesis of the novelFrontiers in microbiology · 2024Review
- Does month of birth influence colorectal cancer prognosis?Langenbeck's archives of surgery · 2023Observational
- Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster.PloS one · 2023Article
- Determination of biomarkers associated with neoadjuvant treatment response focusing on colibactin-producingBMJ open · 2022Article
- Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2022Review
- Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention.Frontiers in immunology · 2022Review
- Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan.Cancer science · 2022Article
- Reply to Dubbert and von Bünau, "A Probiotic Friend".mSphere · 2021Article
- Tackling the Threat of Cancer Due to Pathobionts Producing Colibactin: Is Mesalamine the Magic Bullet?Toxins · 2021Review
- Colibactin in avian pathogenicVirulence · 2021Article
- Review
- Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria.BMC microbiology · 2021Article
- Article
- Stool pattern is associated with not only the prevalence of tumorigenic bacteria isolated from fecal matter but also plasma and fecal fatty acids in healthy Japanese adults.BMC microbiology · 2021Article
Corrections and comments
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Authors and funding
20 authors at 14 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which a large proportion produces a genotoxin called colibactin. In order to analyze the short- and long-term effects resulting from such evolution, we developed a rat model mimicking the natural transmission of E. coli from mothers to neonates. Genotoxic and non-genotoxic E. coli strains were equally transmitted to the offspring and stably colonized the gut across generations. DNA damage was only detected in neonates colonized with genotoxic E. coli strains. Signs of genotoxic stress such as anaphase bridges, higher occurrence of crypt fission and accelerated renewal of the mature epithelium were detected at adulthood. In addition, we observed alterations of secretory cell populations and gut epithelial barrier. Our findings illustrate how critical is the genotype of E. coli strains acquired at birth for gut homeostasis at adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.