ArticleLangmuir : the ACS journal of surfaces and colloids2014
Potential toxicity of up-converting nanoparticles encapsulated with a bilayer formed by ligand attraction.
Article in Langmuir : the ACS journal of surfaces and colloids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- Toxicity of Large and Small Surface-Engineered Upconverting Nanoparticles for In Vitro and In Vivo Bioapplications.International journal of molecular sciences · 2024Article
- Initial Biological Assessment of Upconversion Nanohybrids.Biomedicines · 2021Article
- Recent Advances of Upconversion Nanomaterials in the Biological Field.Nanomaterials (Basel, Switzerland) · 2021Review
- Nanocurcumin-Loaded UCNPs for Cancer Theranostics: Physicochemical Properties, In Vitro Toxicity, and In Vivo Imaging Studies.Nanomaterials (Basel, Switzerland) · 2021Article
- Optically Robust and Biocompatible Mechanosensitive Upconverting Nanoparticles.ACS central science · 2019Article
- Upconverting SrFScientific reports · 2019Article
- Article
- Breakthroughs in medicine and bioimaging with up-conversion nanoparticles.International journal of nanomedicine · 2019Review
- [Research advance of lateral flow assay labels].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018Review
- Highly efficient upconversion of ErScientific reports · 2017Article
- The effect of core and lanthanide ion dopants in sodium fluoride-based nanocrystals on phagocytic activity of human blood leukocytes.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2017Article
- Probing the interactions of CdTe quantum dots with pseudorabies virus.Scientific reports · 2015Article
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3 authors.
Funding
Abstract
The cellular toxicity of nanoparticles that were capped with a bilayered ligand was studied using an up-converting (UC) phosphor material as a representative nanoparticle (NP). The results indicate that although UC NPs are known to be nontoxic, the toxicity of the NPs depends strongly on ligand coordination conditions, in addition to the other commonly known parameters such as size, structure, surface charge etc. Oleate-capped hydrophobic NaYF4:Yb,Er NPs were surface modified to yield three extreme conditions: bare particles that were stripped of the oleate ligands; particles with covalently bound poly(ethylene glycol) (PEG) ligands; and particles with an bilayer of PEG-oleate ligands using the oleate surface group that was remained after synthesis. It was found that the bare particles and the covalent PEG NPs induced little toxicity. However, particles that were rendered biocompatible by forming a bilayer with an amphiphilic ligand (i.e., PEG-oleate) resulted in significant cell toxicity. These findings strongly suggest that the PEG-oleate group dissociated from the bilayered oleate-capped NPs, resulting in significant toxicity by exposing the hydrophobic oleate-capped NPs to the cell. Based on results with bare particles, the NaLnF4:Yb,Er (Ln = Y, Gd) up-converting phosphors are essentially less-toxic. Capping and functionalizing these particles with ligand intercalation may, however, not be a suitable method for rendering the NPs suitable for bioapplication as the ligand can potentially dissociate upon cellular interaction, leading to significant toxicity.
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