ArticlePloS one2014
Single-cell-precision microplasma-induced cancer cell apoptosis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effects and safety of atmospheric low-temperature plasma on bacterial reduction in chronic wounds and wound size reduction: A systematic review and meta-analysis.International wound journal · 2019Pooled it
- Dexamethasone enhances cold atmospheric-pressure plasma-induced antitumor effects in lung adenocarcinoma partly through ROS-associated apoptosis and suppression of PI3K/AKT signaling.Scientific reports · 2026Article
- Defects in Mitochondrial Functions Affect the Survival of Yeast Cells Treated with Non-Thermal Plasma.International journal of molecular sciences · 2023Article
- Enhancing the Impact of Chemotherapy on Ewing Sarcoma Cells through Combination with Cold Physical Plasma.International journal of molecular sciences · 2023Article
- In vitro and in vivo research of atmosphere pressure nonequilibrium plasmas on root canal disinfection: implication for alternative strategy for irrigation.Clinical oral investigations · 2021Article
- Effects of Non-Thermal Plasma on YeastInternational journal of molecular sciences · 2021Review
- Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher Sensitivity for the High-Grade Cell Line.Biology · 2021Article
- Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.International journal of molecular sciences · 2020Review
- Article
- Cold Atmospheric Plasma Is a Potent Tool to Improve Chemotherapy in Melanoma In Vitro and In Vivo.Biomolecules · 2020Article
- Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine.International journal of molecular sciences · 2020Review
- Non-Thermal Plasma-Induced Immunogenic Cell Death in Cancer: A Topical Review.Journal of physics D: Applied physics · 2019Article
- The protective action of osmolytes on the deleterious effects of gamma rays and atmospheric pressure plasma on protein conformational changes.Scientific reports · 2017Article
- A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo.Cancers · 2017Article
- Review
- Non-equilibrium plasma prevention of Schistosoma japonicum transmission.Scientific reports · 2016Article
- Utilizing the micron sized non-thermal atmospheric pressure plasma inside the animal body for the tumor treatment application.Scientific reports · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The issue of single-cell control has recently attracted enormous interest. However, in spite of the presently achievable intracellular-level physiological probing through bio-photonics, nano-probe-based, and some other techniques, the issue of inducing selective, single-cell-precision apoptosis, without affecting neighbouring cells remains essentially open. Here we resolve this issue and report on the effective single-cell-precision cancer cell treatment using the reactive chemistry of the localized corona-type plasma discharge around a needle-like electrode with the spot size ∼1 µm. When the electrode is positioned with the micrometer precision against a selected cell, a focused and highly-localized micro-plasma discharge induces apoptosis in the selected individual HepG2 and HeLa cancer cells only, without affecting any surrounding cells, even in small cell clusters. This is confirmed by the real-time monitoring of the morphological and structural changes at the cellular and cell nucleus levels after the plasma exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.