Evidence map›Paper›PMID 24971329›Full record

ArticleBioMed research international2014

Tissue extracellular matrix nanoparticle presentation in electrospun nanofibers.

Matt Gibson, Vince Beachley, Jeannine Coburn, Pierre Alain Bandinelli, Hai-Quan Mao, Jennifer Elisseeff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Shape Memory Polymer Scaffolds-Utility for In Vitro Osteogenesis of Canine Multipotent Stromal Cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2024
    Article
  3. Review
  4. Article
  5. Article
  6. Polymeric nanofibrous scaffolds laden with cell-derived extracellular matrix for bone regeneration.Materials science & engineering. C, Materials for biological applications · 2020
    Article
  7. Article
  8. Co-culture cell-derived extracellular matrix loaded electrospun microfibrous scaffolds for bone tissue engineering.Materials science & engineering. C, Materials for biological applications · 2019
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matt GibsonTranslational Tissue Engineering Center and Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Vince BeachleyTranslational Tissue Engineering Center and Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-8274-1173
Jeannine CoburnTranslational Tissue Engineering Center and Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0001-6354-5436
Pierre Alain BandinelliTranslational Tissue Engineering Center and Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-2808-6112
Hai-Quan MaoTranslational Tissue Engineering Center and Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA ; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
Jennifer ElisseeffTranslational Tissue Engineering Center and Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA ; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.

Funding

Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2011 to 2020
$12.0M
Chondroitin sulfate-fiber hydrogels for cartilage tissue engineeringF31AG033999 · NIA · JOHNS HOPKINS UNIVERSITY · PI COBURN, JEANNINE · 2009 to 2012
$102k
NIA NIH HHS F31 AG033999NIDDK NIH HHS P30 DK089502
6 · The paper itself

Abstract

Biomaterials derived from the decellularization of mature tissues retain biological and architectural features that profoundly influence cellular activity. However, the clinical utility of such materials remains limited as the shape and physical properties are difficult to control. In contrast, scaffolds based on synthetic polymers can be engineered to exhibit specific physical properties, yet often suffer from limited biological functionality. This study characterizes composite materials that present decellularized extracellular matrix (DECM) particles in combination with synthetic nanofibers and examines the ability of these materials to influence stem cell differentiation. Mechanical processing of decellularized tissues yielded particles with diameters ranging from 71 to 334 nm. Nanofiber scaffolds containing up to 10% DECM particles (wt/wt) derived from six different tissues were engineered and evaluated to confirm DECM particle incorporation and to measure bioactivity. Scaffolds containing bone, cartilage, and fat promoted osteogenesis at 1 and 3 weeks compared to controls. In contrast, spleen and lung DECM significantly reduced osteogenic outcomes compared to controls. These findings highlight the potential to incorporate appropriate source DECM nanoparticles within nanofiber composites to design a scaffold with bioactivity targeted to specific applications.

Indexed as

Adipose TissueBiomarkersCell CommunicationCell ShapeCell SurvivalExtracellular MatrixGene Expression RegulationHumansNanofibersNanoparticlesOsteogenesisStem CellsTissue EngineeringTissue ScaffoldsWaterBiomarkersWater

Identifiers

PMID24971329
PMCPMC4058126

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.