ArticleBioMed research international2014
Fluorescence-guided surgery and biopsy in gliomas with an exoscope system.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 8 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Sodium fluorescein and 5-aminolevulinic acid fluorescence- guided biopsy in brain lesions: a systematic review and meta-analysis.Journal of neuro-oncology · 2024Pooled it
- A systematic review and meta-analysis of fluorescent-guided resection and therapy-based photodynamics on the survival of patients with glioma.Lasers in medical science · 2022Pooled it
- Intraoperative 5-ALA fluorescence-guided resection of high-grade glioma leads to greater extent of resection with better outcomes: a systematic review.Journal of neuro-oncology · 2022Pooled it
- Intraoperative fluorescence diagnosis in the brain: a systematic review and suggestions for future standards on reporting diagnostic accuracy and clinical utility.Acta neurochirurgica · 2019Pooled it
- Survival Outcomes Among Patients With High-Grade Glioma Treated With 5-Aminolevulinic Acid-Guided Surgery: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2019Pooled it
- Various shades of red-a systematic analysis of qualitative estimation of ALA-derived fluorescence in neurosurgery.Neurosurgical review · 2018Pooled it
- Agents for fluorescence-guided glioma surgery: a systematic review of preclinical and clinical results.Acta neurochirurgica · 2017Pooled it
- 5-ALA Fluorescence Image Guided Resection of Glioblastoma Multiforme: A Meta-Analysis of the Literature.International journal of molecular sciences · 2015Pooled it
- Monitor-based exoscopic 3D4k neurosurgical interventions: a two-phase prospective-randomized clinical evaluation of a novel hybrid device.Acta neurochirurgica · 2020Trial
- Exoscope-Assisted Spine Surgery: A Systematic Review From Basic to Complex Pathologies.Cureus · 2025Review
- The 3D-Robotic Exoscope Compared With the Microscope in Cochlear Implant and Translabyrinthine Surgery.The Laryngoscope · 2025Article
- Comparative analysis of exoscope-assisted spine surgery versus operating microscope: A systematic review.World neurosurgery: X · 2024Review
- Second-Generation Wide-Field Visualization Devices for 5-ALA-Induced Fluorescence and Concepts for Validation in Neurosurgery-A Systematic Review.Neurosurgery practice · 2023Review
- Exoscopic Microsurgery: A Change of Paradigm in Brain Tumor Surgery? Comparison with Standard Operative Microscope.Brain sciences · 2023Article
- Commentary: A Novel 5-Aminolevulinic Acid-Enabled Surgical Loupe System-A Consecutive Brain Tumor Series of 11 Cases.Operative neurosurgery (Hagerstown, Md.) · 2022Article
- Visualization, navigation, augmentation. The ever-changing perspective of the neurosurgeon.Brain & spine · 2022Review
- The Exoscope in Neurosurgery: An Overview of the Current Literature of Intraoperative Use in Brain and Spine Surgery.Journal of clinical medicine · 2021Review
- Review
- Evaluation of 3D Robotic-Guided Exoscopic Visualization in Microneurosurgery.Frontiers in surgery · 2021Article
- Characteristics of Fluorescent Intraoperative Dyes Helpful in Gross Total Resection of High-Grade Gliomas-A Systematic Review.Diagnostics (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe introduction of fluorescence-guided resection allows a better identification of tumor tissue and its more radical resection. We describe our experience with a modified exoscope to detect 5 ALA-induced fluorescence in neuronavigation-guided brain surgery or biopsy of malignant brain tumors.
methodsThirty-eight patients with a suspected preoperative diagnosis of high-grade astrocytoma were included. We used a neuronavigation device and a high-definition exoscope system with a built-in filter to detect 5-ALA fluorescence in all cases. Thirty patients underwent craniotomy with tumor resection and 8 underwent frameless stereotactic brain biopsy.
resultsHistopathological diagnosis confirmed the presence of high-grade gliomas in 34 patients. Total resection was achieved in 23 cases and subtotal in 7. No relevant complications related to the administration of 5-ALA were detected.
conclusionsThe use of the exoscope in 5-ALA fluorescence-guided tumor surgery has twofold implications: during brain tumor surgery it can be considered a valuable tool to achieve a more radical resection of the lesion, and when applied to a biopsy of a suspected brain high-grade glioma, it decreases the possibility of a negative biopsy.
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