Evidence map›Paper›PMID 24971316›Full record

ArticleBioMed research international2014

ATP during early bladder stretch is important for urgency in detrusor overactivity patients.

Y Cheng, K J Mansfield, W Allen, R Chess-Williams, E Burcher, K H Moore

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PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Y ChengDepartment of Urogynaecology, St George Hospital, University of New South Wales, Level 1, W.R. Pitney Building, Sydney, NSW 2217, Australia.
K J MansfieldGraduate School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia.
W AllenDepartment of Urogynaecology, St George Hospital, University of New South Wales, Level 1, W.R. Pitney Building, Sydney, NSW 2217, Australia.
R Chess-WilliamsFaculty of Health Sciences & Medicine, Bond University, Gold Coast, QLD 4229, Australia.
E BurcherDepartment of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
K H MooreDepartment of Urogynaecology, St George Hospital, University of New South Wales, Level 1, W.R. Pitney Building, Sydney, NSW 2217, Australia.
St George Hospital · AUUNSW Sydney · AUBond University · AUUniversity of Wollongong · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ATP is an important mediator of urgency in women with detrusor overactivity (DO). In order to understand how different degrees of bladder stretch elicited ATP release in DO patients compared with controls, sequential aliquots were collected during cystometry and ATP release was measured at each degree of bladder filling, in female patients with DO and controls. In both DO and control groups, ATP release was induced during bladder filling, suggesting that stretch stimulated further ATP release. However, the luminal ATP concentrations were already high at early filling stage (200 mL), which was even greater than those at the later filling stages (400 mL and maximum cystometric capacity, MCC), indicating that a substantial ATP release has been induced during early filling (200 mL) in both DO and controls. In DO, ATP release at 200 mL was significantly higher in those with low first desire to void (FDV) (≤ 200 mL) than in those with higher FDV (> 200 mL); this may suggest that ATP release at early stretch may play an important role in urgency (early sensation) in DO. ATP concentrations remained unchanged after voiding, suggesting that voiding did not further induce ATP release into intraluminal fluid.

Indexed as

Adenosine TriphosphateAdultAgedAged, 80 and overFemaleHumansMiddle AgedSensationUrinary Bladder, OveractiveUrinary Incontinence, StressUrinationAdenosine Triphosphate

Identifiers

PMID24971316
PMCPMC4058262
OpenAlexW2025107059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.