Evidence map›Paper›PMID 24971227›Full record

ArticleJournal of addiction research & therapy2013

Genospirituality: Our Beliefs, Our Genomes, and Addictions.

Kenneth Blum, Benjamin Thompson, Marlene Oscar-Berman, John Giordano, Eric Braverman, John Femino, Debmayla Barh, William Downs, Thomas Smpatico, Stephen Schoenthaler

Open access · hybridAbstract read
In one paragraph

Article in Journal of addiction research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kenneth BlumDepartment of Psychiatry, McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA ; Department of Clinical Research, LLC National Institute for Holistic Addiction Studies Inc., North Miami Beach, FL, USA ; Department of Clinical Neurology, PATH Foundation NY, New York, NY, USA ; Institute of Integrative Omics & Applied Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India ; Department of Addiction Research & Therapy, Malibu Beach Recovery Center, Malibu Beach, CA, USA ; Dominion Diagnostics, LLC, North Kingstown, RI, USA ; Department of Genomics, IGENE, LLC, Austin, TX, USA.
Benjamin ThompsonBehavioral Neuroscience Ph.D. Program, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA.
Marlene Oscar-BermanDepartments of Psychiatry and Anatomy & Neurobiology, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA.
John GiordanoDepartment of Clinical Research, LLC National Institute for Holistic Addiction Studies Inc., North Miami Beach, FL, USA.
Eric BravermanDepartment of Psychiatry, McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA ; Department of Clinical Neurology, PATH Foundation NY, New York, NY, USA.
John FeminoDepartment of Clinical Medicine, Meadowsedge Recovery Center, North Kingstown, RI, USA.
Debmayla BarhInstitute of Integrative Omics & Applied Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India.
William DownsDepartment of Genomics, IGENE, LLC, Austin, TX, USA.
Thomas SmpaticoDepartment of Psychiatry, Human Integrated Services Unit University of Vermont Center for Clinical & Translational Science, College of Medicine, Burlington, VT, USA.
Stephen SchoenthalerDepartment of Clinical Research, LLC National Institute for Holistic Addiction Studies Inc., North Miami Beach, FL, USA ; Department of Sociology, California State University, Turlock, CA, USA.
Institute of Bioinformatics and Applied Biotechnology · IN

Funding

AFFECTIVE AND CONATIVE CHANGES IN ALCOHOLISMR01AA007112 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BERMAN, MARLENE OSCAR · 1987 to 2019
$8.3M
AFFECTIVE AND CONATIVE CHANGES IN ALCOHOLISMK05AA000219 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BERMAN, MARLENE OSCAR · 1997 to 2011
$1.8M
NIAAA NIH HHS K05 AA000219NIAAA NIH HHS R01 AA007112
6 · The paper itself

Abstract

Addictions to smoking, alcohol, illicit drugs, and certain behaviors like gambling, overeating, and sex, are prevalent worldwide. These behaviors are highly destructive and costly to individuals and society due to health consequences, criminality and lost productivity. The genetic vulnerability, environmental exposures, and individual behaviors that contribute to the brain dysfunction and compulsive tendencies that mark addiction make it one of the most complicated diseases to study and treat. Although much has been learned about the genetic basis of and biochemical imbalances associated with the addictions, research leading to effective treatments has been slow. Addictions are often accompanied by an inner sense of disintegration, enslavement and meaninglessness that can be viewed in terms of a spiritual craving for wholeness, freedom, and transformation. Arguably, progress towards effective treatment has been retarded by insufficient attention being paid to understanding the role of spirituality in helping to heal addicts. Assuming one accepts the belief that the brain mediates all conscious and unconscious experiences- including spiritually experiences -healing, like addictions, can be related to the processes by which the human brain is organized for controlling pleasure and pain. Here we hypothesize that a healthy spirituality may come more naturally to some individuals because of the unique interaction of their genes and their environments, and we review the evidence in support of this view.

Indexed as

Addiction recoveryDopaminergicGenesReward Deficiency Syndrome (RDS)Reward dependenceSpiritualityTwelve steps

Identifiers

PMID24971227
PMCPMC4068016
OpenAlexW2129727531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.