Evidence map›Paper›PMID 24971086›Full record

ReviewFrontiers in genetics2014

Progress and challenge of microRNA research in immunity.

Hyang-Mi Lee, Duc T Nguyen, Li-Fan Lu

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. The miRNome of Depression.International journal of molecular sciences · 2021
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. BioMed research international · 2020
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hyang-Mi LeeDivision of Biological Sciences, University of California, San Diego La Jolla, CA, USA.
Duc T NguyenDivision of Biological Sciences, University of California, San Diego La Jolla, CA, USA.
Li-Fan LuDivision of Biological Sciences, University of California, San Diego La Jolla, CA, USA ; Moores Cancer Center, University of California, San Diego La Jolla, CA, USA.

Funding

Role of microRNAs in regulatory T cell-mediated immunological tolerance and T celR01AI108651 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2014 to 2024
$4.0M
Function of microRNAs in controlling regulatory T cell biologyR00AI089935 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2012 to 2013
$493k
The role of SOCS1 repression by miR-155 in regulating immune responsivenessR21AI103646 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LU, LI-FAN · 2013 to 2014
$426k
NIAID NIH HHS R00 AI089935NIAID NIH HHS R01 AI108651NIAID NIH HHS R21 AI103646
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are 19-24 nucleotide long non-coding RNA species that regulate the expression of multiple target genes at the post-transcriptional level. They are required for normal immune system development and function, and their expression is dynamically regulated in different immune cell subsets during lineage differentiation and immune response. Aberrant expression of miRNAs results in dysregulated innate and adaptive immunity. This in turn can lead to failure to fight against invading pathogens and the development of autoimmune diseases and hematopoietic malignancies. In this article, we review current progress in miRNA research in immunity in both physiological and pathological settings. We also discuss research limitations and challenges that researchers are just beginning to solve.

Indexed as

hematopoiesisimmune dysfunctionimmune regulationmicroRNA (miRNA)post-transcriptional regulation

Identifiers

PMID24971086
PMCPMC4053854

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.