ArticleFrontiers in aging neuroscience2014
Motor-Language Coupling in Huntington's Disease Families.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Dynamics of language grounding: on the time course, durability, adaptability, and vulnerability of embodied effects.Frontiers in psychology · 2025Review
- Flexible and fine-grained simulation of speed in language processing.Frontiers in psychology · 2024Article
- Spatiotemporal Dynamics of Activation in Motor and Language Areas Suggest a Compensatory Role of the Motor Cortex in Second Language Processing.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Ecological Meanings: A Consensus Paper on Individual Differences and Contextual Influences in Embodied Language.Journal of cognition · 2023Article
- Understanding speech and swallowing difficulties in individuals with Huntington disease: Validation of the HDQLIFE Speech Difficulties and Swallowing Difficulties Item Banks.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- From discourse to pathology: Automatic identification of Parkinson's disease patients via morphological measures across three languages.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- From action to abstraction: The sensorimotor grounding of metaphor in Parkinson's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington's disease.Brain and behavior · 2019Article
- Embodied Semantics in a Second Language: Critical Review and Clinical Implications.Frontiers in human neuroscience · 2019Review
- Progressive Compromise of Nouns and Action Verbs in Posterior Cortical Atrophy.Frontiers in psychology · 2018Article
- Action Semantics at the Bottom of the Brain: Insights From Dysplastic Cerebellar Gangliocytoma.Frontiers in psychology · 2018Article
- Embodied Cognition: A Challenging Road for Clinical Neuropsychology.Frontiers in aging neuroscience · 2017Article
- Dementia in Latin America: An Emergent Silent Tsunami.Frontiers in aging neuroscience · 2016Article
- Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease.Scientific reports · 2015Article
- Two-person neuroscience and naturalistic social communication: the role of language and linguistic variables in brain-coupling research.Frontiers in psychiatry · 2014Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditionally, Huntington's disease (HD) has been known as a movement disorder, characterized by motor, psychiatric, and cognitive impairments. Recent studies have shown that motor and action-language processes are neurally associated. The cognitive mechanisms underlying this interaction have been investigated through the action compatibility effect (ACE) paradigm, which induces a contextual coupling of ongoing motor actions and verbal processing. The present study is the first to use the ACE paradigm to evaluate action-word processing in HD patients (HDP) and their families. Specifically, we tested three groups: HDP, healthy first-degree relatives (HDR), and non-relative healthy controls. The results showed that ACE was abolished in HDP as well as HDR, but not in controls. Furthermore, we found that the processing deficits were primarily linguistic, given that they did not correlate executive function measurements. Our overall results underscore the role of cortico-basal ganglia circuits in action-word processing and indicate that the ACE task is a sensitive and robust early biomarker of HD and familial vulnerability.
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